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GenomicsZrf1 is required to establish and maintain neural progenitor identity (ChIP-Seq)
We report ChIP-seq data for Zrf1 and Ring1B occupancy in NPC Examination and comparison of DNA binding profile of Zrf1 and Ring1B in NPC
ORGANISM(S): Mus musculus 
2013-12-21 | E-GEOD-53540 | biostudies-arrayexpress
TranscriptomicscDNA microarray analysis of miR-1 transfected HeLa and NPC-TW01 cells
To investigate the mechanisms of miR-1 inducing apoptosis, we performed cDNA expression microarray analysis to identify the candidate miR-1 regulating genes that are involved in apoptosis. NPC-TW01 cells were transfected with miR-1 or miR-negative control for 40 hours, their total RNA were isolated ...
ORGANISM(S): Homo sapiens 
2011-04-13 | E-GEOD-28522 | biostudies-arrayexpress
UnknownA perinuclear α-helix with amphipathic features in Brl1 promotes NPC assembly.
Not available
S-EPMC9282021 | biostudies-literature
ProteomicsThe nucleoporin Nup50 activates the Ran guanyl-nucleotide exchange factor RCC1 to promote NPC assembly at the end of mitosis
During mitotic exit, thousands of nuclear pore complexes (NPCs) assemble concomitant with the nuclear envelope to build a transport-competent nucleus. Here, we show that Nup50 plays a crucial role in NPC assembly independent of its well-established function in nuclear transport. RNAi-mediated downre...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD028701 | Pride
Ap-ms Nuclear pore complex Xenopus 
TranscriptomicsIdentification of the mRNAs interacting with the Nup59 nucleoporin using RNA-IP and microarrays in budding yeast
To specifically explore such mRNA localization events, we immunopurified the entire Nuclear Pore Complex scaffold using Nup59 as a bait and systematically analyzed all co-isolating mRNAs using Agilent microarrays in the budding yeast Saccharomyces cerevisiae. A mock IP was performed as a control exp...
ORGANISM(S): Saccharomyces cerevisiae 
2021-03-31 | E-MTAB-9521 | biostudies-arrayexpress
TranscriptomicsThe genomic landscape of nasopharyngeal carcinoma
Nasopharyngeal carcinoma (NPC) has extremely skewed ethnic and geographic distributions, is poorly understood at the genetic level and is in need of effective therapeutic approaches. Here we determined the mutational landscape of 128 cases with NPC using whole-exome and targeted deep sequencing, as ...
ORGANISM(S): Homo sapiens 
2014-11-18 | E-GEOD-63381 | biostudies-arrayexpress
ProteomicsMaturation kinetics of a multiprotein complex revealed by metabolic labeling
The project aims at computing in vivo co-assembly kinetics from metabolomic-inspired approaches. In short, we performed reciprocal pull-down experiments from complex cellular components at different time points following pulsed-SILAC metabolic labeling. We applied the method to 320 pairs of yeast nu...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2020-10-16 | PXD018034 | Pride
Data independent acquisition Maturation kinetics Yeast Pulsed silac Nuclear pore complex 
GenomicsGenomic analysis Nasopharyngeal cancer through whole exome sequencing and whole genomic sequencing.
Nasopharyngeal carcinoma (NPC) is a squamous-cell carcinoma and has remarkable ethnic and geographic distribution, with a high prevalence in southern China, southeast Asia, northern Africa and Alaska. Although there are previous studies implicated NF-κB pathway play an important role in NPC. Newer r...
EGAS00001002788 | EGA
TranscriptomicsEpigenetic profile of iPSC differentiation process by scGET-seq
Induced pluripotent stem cells (iPSC) derived from fibroblasts of two healthy individuals were differentiated into NPC. Cells were profiled by scGET-seq.
ORGANISM(S): Homo sapiens 
2021-08-17 | E-MTAB-9649 | biostudies-arrayexpress
TranscriptomicsEpigenetic profile of iPSC differentiation process by scGET-seq
Induced pluripotent stem cells (iPSC) derived from fibroblasts of two healthy individuals were differentiated into NPC. Cells were profiled by scGET-seq.
ORGANISM(S): Homo sapiens 
2021-08-17 | E-MTAB-10218 | biostudies-arrayexpress
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