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GenomicsAnalysis of Nr1h2 and H3K27ac genomic binding targets in ESC and EPSC under Nr1h2 activation
Analysis of Nr1h2 and H3K27ac genomic binding targets in ESC and EPSC under Nr1h2 activation
PRJNA900609 | ENA
ProteomicsMouse ESC Nr1h2 interactome under T09 treatment
The intrinsic regulators of stem cell-based embryo models are not well studied. We show that Nr1h2 activation enables conventional ESCs to form blastoids with better implantation and higher blastocyst rates. We identified Nr1h2 transcriptional interactome by CoIP-MS using FLAG antibody to immunoprec...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-28 | PXD057257 | Pride
T0901317 Ap-ms Mouse Embryonic stem cells Nr1h2 
GenomicsAnalysis of Nr1h2 and H3K27ac genomic binding targets in ESC and EPSC under Nr1h2 activation
ChIP-seq for Nr1h2 in NrESC, ESC. H3K27ac ChIP-seq in NrESC, ESC, EPSC, EPSCT09 Embryonic stem cells upon extrinsic induction could self-assemble into blastocyst-like structures. However, the intrinsic regulation of such blastoid forming potential remain to be addressed. We discover that the activit...
ORGANISM(S): Mus musculus 
2024-10-23 | GSE217824 | GEO
UnknownA common polymorphism in NR1H2 (LXRbeta) is associated with preeclampsia.
Not available
S-EPMC3214159 | biostudies-literature
ProteomicsMARCH2 prevents doxorubicin-induced cardiomyopathy by stabilizing NR1H2 and promoting clearance of apoptotic cardiomyocytes
Doxorubicin-induced cardiomyopathy (DiCM) is a leading cause of heart failure and mortality in cancer patients, with doxorubicin-induced cardiomyocyte apoptosis constituting a fundamental pathological mechanism. Cardiac resident macrophages are primarily responsible for the effective clearance of ap...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-15 | PXD072759 | Pride
Anthracyclines  macrophage  march2  heart failure  mice 
UnknownSignificant association of LXRβ (NR1H2) polymorphisms (rs28514894, rs2303044) with type 2 diabetes mellitus and laboratory characteristics.
Not available
S-EPMC8212291 | biostudies-literature
GenomicsTranscriptomic profiling of LLC LeptoM vector control, Nr1h2/3 DKO and RXRa/b/g TKO upon stimulation with 1μM 9 cis-retinoic acid (RA) in vitro
Transcriptomic profiling of LLC LeptoM vector control, Nr1h2/3 DKO and RXRa/b/g TKO upon stimulation with 1μM 9 cis-retinoic acid (RA) in vitro
PRJNA1162927 | ENA
TranscriptomicsTranscriptomic profiling of LLC LeptoM vector control, Nr1h2/3 DKO and RXRa/b/g TKO upon stimulation with 1μM 9 cis-retinoic acid (RA) in vitro
To understand transcriptional regulation of nuclear receptors, LXRs and RXRs, in leptomeningeal metastatic cancer cells, we use CRISPR-Cas9 to knockout Nr1h2/3 genes (encoding LXRβ/α) or RXRa/b/g genes (encoding RXRα/β/γ) in LLC LeptoM cell lines, with small guide RNA targeting lacZ as vector contro...
ORGANISM(S): Mus musculus 
2024-10-13 | GSE277622 | GEO
Methylation profilingGenome-wide DNA methylation pattern changes in ESC, and EPSC after treated with T09
Embryonic stem cells upon extrinsic induction could self-assemble into blastocyst-like structures. However, the intrinsic regulation of such blastoid forming potential remain to be addressed. We discover that the activity of nuclear receptor subfamily 1, group H, member 2 (Nr1h2) in expanded potenti...
ORGANISM(S): Mus musculus 
2024-10-23 | GSE244019 | GEO
GenomicsATAC-seq in NrESC
ATAC-seq in NrESC_1, NrESC_16, ESC, EPSC Embryonic stem cells upon extrinsic induction could self-assemble into blastocyst-like structures. However, the intrinsic regulation of such blastoid forming potential remain to be addressed. We discover that the activity of nuclear receptor subfamily 1, grou...
ORGANISM(S): Mus musculus 
2024-10-23 | GSE217825 | GEO
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