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TranscriptomicsThe MOF-containing NSL complex associates globally with housekeeping genes, but activates only a defined subset (RNAi)
The MOF-containing NSL complex binds to many but not all promoters of active genes and potentially contributes to their proper gene expression. It is currently unknown what determines whether an active gene is bound or not. Here, we provide evidence that the NSL complex primarily targets active prom...
ORGANISM(S): Drosophila melanogaster 
2011-10-28 | E-GEOD-30990 | biostudies-arrayexpress
TranscriptomicsThe MOF-containing NSL complex associates globally with housekeeping genes, but activates only a defined subset (ChIP)
The MOF-containing NSL complex binds to many but not all promoters of active genes and potentially contributes to their proper gene expression. It is currently unknown what determines whether an active gene is bound or not. Here, we provide evidence that the NSL complex primarily targets active prom...
ORGANISM(S): Drosophila melanogaster 
2011-10-28 | E-GEOD-30989 | biostudies-arrayexpress
TranscriptomicsThe MOF-containing NSL complex associates globally with housekeeping genes, but activates only a defined subset
This SuperSeries is composed of the following subset Series: GSE30989: MOF-containing NSL complex specifically binds promoters of most, but stimulates only a specific subset of, housekeeping genes (ChIP-chip dataset) GSE30990: MOF-containing NSL complex specifically binds promoters of most, but stim...
ORGANISM(S): Drosophila melanogaster 
2011-10-28 | E-GEOD-30991 | biostudies-arrayexpress
GenomicsAnalysis of NSL knockout brains
Analysis of NSL knockout brains
PRJNA577934 | ENA
ProteomicsPHF20 and PHF20L1 in NSL complex
The methyl lysine readers PHF (plant homeodomain finger) 20 (PHF20) and its homolog PHF20 Like 1 (PHF20L1) are known components of the NSL (non-specific lethal) complex that regulates gene expression through its histone acetyltransferase activity. In the current model, both PHF homologs coexist in t...
ORGANISM(S): Homo sapiens (Human) 
2022-04-04 | PXD029258 | Pride
Ap-ms Phf20 Phf20l1 U2os 
GenomicsChIP-seq profiling of RNA Polymerase II in Drosophila melanogaster S2 cells depleted of the non-specific lethal (NSL) complex
We show that the non-specific lethal (NSL) complex in Drosophila binds to housekeeping genes. Individual ChIP-qPCR experiments of NSL target genes indicated a role of the NSL complex in RNA Polymerase II (Pol II) recruitment to promoters. Consequently, we obtained ChIP-Seq profiles of the Pol-II-sub...
ORGANISM(S): Drosophila melanogaster 
2012-06-19 | E-MTAB-1084 | biostudies-arrayexpress
UnknownThe NSL complex regulates housekeeping genes in Drosophila.
Not available
S-EPMC3375229 | biostudies-literature
GenomicsMethyl-lysine readers PHF20 and PHF20L1 define two distinct NSL complexes
Methyl-lysine readers PHF20 and PHF20L1 define two distinct NSL complexes
PRJNA779539 | ENA
GenomicsHangover regulates gene expression by limiting NSL-mediated H4K16 acetylation
Hangover regulates gene expression by limiting NSL-mediated H4K16 acetylation
PRJEB88170 | ENA
ProteomicsComplex-dependent histone acetyltransferase activity of KAT8 determines its role in transcriptional regulation and cellular homeostasis [AP-MS]
Histone acetylation is associated with open chromatin and transcriptionally active genes. Specifically, acetylation of lysine 16 on histone H4 (H4K16ac) has been shown to prevent the assembly of nucleosomal arrays in vitro. This modification is catalyzed by the MYST-family histone acetyltransferase ...
ORGANISM(S): Homo sapiens (Human) 
2021-06-29 | PXD022267 | Pride
Nsl Msl Histone Kat8 
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