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GenomicsNitrosospira sp. Nsp14
Nitrosospira sp. 17 Nsp14 genome sequencing
PRJNA322876 | ENA
GenomicsSARS-CoV-2 NSP14 inhibitor exhibits potent antiviral activity and reverses NSP14-driven host modulation
SARS-CoV-2 NSP14 inhibitor exhibits potent antiviral activity and reverses NSP14-driven host modulation
PRJNA1302786 | ENA
GenomicsSARS-CoV-2 NSP14 Inhibitor Confers Potent Antiviral Efficacy and Reverses NSP14-triggered Host Cell Modulation
SARS-CoV-2 NSP14 Inhibitor Confers Potent Antiviral Efficacy and Reverses NSP14-triggered Host Cell Modulation
PRJNA1226168 | ENA
TranscriptomicsSARS-CoV-2 NSP14 Inhibitor Confers Potent Antiviral Efficacy and Reverses NSP14-triggered Host Cell Modulation
The emergence of SARS-CoV-2 variants and drug-resistant mutants necessitates additional antivirals. SARS-CoV-2 NSP14 N7-guanosine methyltransferase is responsible for viral RNA capping, facilitating replication and evading immune detection. NSP14 has emerged as a promising drug target, but the role ...
ORGANISM(S): Homo sapiens 
2025-09-06 | GSE290079 | GEO
TranscriptomicsSARS-CoV-2 NSP14 inhibitor exhibits potent antiviral activity and reverses NSP14-driven host modulation
The emergence of SARS-CoV-2 variants and drug-resistant mutants underscores the urgent need for novel antiviral therapeutics. SARS-CoV-2 NSP14, an N7-guanosine methyltransferase, plays a critical role in viral RNA capping, enabling viral replication and immune evasion. While NSP14 has emerged as a p...
ORGANISM(S): Chlorocebus sabaeus 
2025-09-06 | GSE304814 | GEO
ProteomicsSARS-CoV-2 nsp14 induces the m7G methylation and the sequestration of host RNAs in stress granules TurboID Biotin-Streptavidin pull-down LC-MSMS
Viruses grab the host translation machinery to facilitate their replication by disturbing the host translation. SARS-CoV-2 nsp14 was known to inhibit host translation, yet the mechanistic details are still obscure. In this study, we report that nsp14 can elevate stress granules (SG) formation in a N...
ORGANISM(S): Homo sapiens (Human) 
2026-02-06 | PXD060759 | Pride
Lc-msms Nsp14 Stress granules Turboid 
ProteomicsSARS-CoV-2 nsp14 induces the m7G methylation and the sequestration of host RNAs in stress granules Twin-Strep Streptactin pull-down LC-MSMS
Viruses grab the host translation machinery to facilitate their replication by disturbing the host translation. SARS-CoV-2 nsp14 was known to inhibit host translation, yet the mechanistic details are still obscure. In this study, we report that nsp14 can elevate stress granules (SG) formation in a N...
ORGANISM(S): Homo sapiens (Human) 
2026-02-06 | PXD060757 | Pride
Lc-msms Nsp14 Twin-strep Stress granules 
TranscriptomicsCoronavirus NSP14 Drives Internal m7G Modification to Rewire Host Splicing and Promote Viral Replication
SARS-CoV-2, the causative agent of COVID-19, manipulates host gene expression through multiple mechanisms, including disruption of RNA processing. Here, we identify a novel function of the viral nonstructural protein 14 (NSP14) in inducing N7-methylguanosine (m7G) modification in the internal sequen...
ORGANISM(S): Homo sapiens 
2025-09-05 | GSE307386 | GEO
GenomicsCoronavirus NSP14 Drives Internal m7G Modification to Rewire Host Splicing and Promote Viral Replication
Coronavirus NSP14 Drives Internal m7G Modification to Rewire Host Splicing and Promote Viral Replication
PRJNA1320633 | ENA
GenomicsSARS-CoV-2 Nsp14 mediates the effects of viral infection on the host cell transcriptome
SARS-CoV-2 Nsp14 mediates the effects of viral infection on the host cell transcriptome
PRJNA743007 | ENA
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