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ProteomicsRevealing the Structural Plasticity of SARS-CoV-2 nsp7 and nsp8 Using Structural Proteomics (HDX-MS)
SARS-CoV-2 nsp7 and nsp8 are important cofactors of the RTC, as they interact and regulate the activity of RNA-dependent RNA polymerase and other nspsHere we used solution-based structural proteomic techniques, hydrogen-deuterium exchange mass spectrometry (HDX-MS) and crosslinking mass spectrometry...
ORGANISM(S): Severe acute respiratory syndrome coronavirus 2 
2022-01-12 | PXD026066 | Pride
Sars-cov-2 Nsp7 Nsp8 Hdx-ms 
ProteomicsThe kinetics of nsp7-11 polyprotein processing and impact on complexation with nsp16 among human coronaviruses
In coronavirus (CoV) infection, polyproteins (pp1a/pp1ab) are processed into non-structural proteins (nsps), which largely form the replication/transcription complex (RTC). The polyprotein processing and complex formation is critical and offers potential therapeutic targets. However, the interplay o...
ORGANISM(S): Escherichia coli 
2025-07-08 | PXD049009 | Pride
Mass spectrometry Sars-cov-2 Kinetics Native ms Rate constants Complexation 
ProteomicsRevealing the Structural Plasticity of SARS-CoV-2 nsp7 and nsp8 Using Structural Proteomics (XL-MS)
SARS-CoV-2 nsp7 and nsp8 are important cofactors of the RTC, as they interact and regulate the activity of RNA-dependent RNA polymerase and other nspsHere we used solution-based structural proteomic techniques, hydrogen-deuterium exchange mass spectrometry (HDX-MS) and crosslinking mass spectrometry...
ORGANISM(S): Severe acute respiratory syndrome coronavirus 2 
2022-01-12 | PXD026191 | Pride
Sars-cov-2 Xl-ms Nsp7 Nsp8 
Genomics
NSP7 Molecule Degrader Suppresses Coronavirus Infection
PRJNA1206177 | ENA
ProteomicsSelennoprotein S interacts with the replication and transcription complex of the SARS-CoV-2 by binding nsp7
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) replicates and evades detection by using endoplasmic reticulum (ER) membranes and their associated protein machineries. Among these hijacked human ER proteins is selenoprotein S, which usually takes part in the ER protein degradation p...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD038629 | Pride
Selenos Nsp12 Nsp8 Covid-19 Vimp 
UnknownNSP7 Molecular Degrader Attenuates Coronaviral Infection Through the β-TrCP1/FBXO5 Axis.
Not available
S-EPMC12463105 | biostudies-literature
UnknownRevealing the Structural Plasticity of SARS-CoV-2 nsp7 and nsp8 Using Structural Proteomics.
Not available
S-EPMC8231661 | biostudies-literature
UnknownProcessing of the SARS-CoV pp1a/ab nsp7-10 region.
Not available
S-EPMC7078746 | biostudies-literature
UnknownResolving the Dynamic Motions of SARS-CoV-2 nsp7 and nsp8 Proteins Using Structural Proteomics.
Not available
S-EPMC7941636 | biostudies-literature
UnknownSARS-CoV-2 Nsp7 plays a role in cognitive dysfunction by impairing synaptic plasticity.
Not available
S-EPMC11617585 | biostudies-literature
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