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ProteomicsProteomics characterization of NTRK1/TrkA signaling in neuroblastoma cells reveals intra-nuclear aggregation of Lamin A/C
Simple Summary: Neuroblastoma (NB) accounts for 15% of all cancer related deaths of children. While amplification of the Myc-N proto-oncogene (MYCN) is a major driver of NB, expression of the neurotrophin receptor, NTRK1/TrkA, has been shown to associate with an excellent outcome. MYCN down-regulate...
ORGANISM(S): Homo sapiens (Human) 
2021-11-11 | PXD026876 | Pride
Neuroblastoma Mycn Nuclear foci Trka Ntrk1 
ProteomicsProteomics characterization of NTRK1/TrkA signaling in neuroblastoma cells reveals intra-nuclear aggregation of Lamin A/C
Simple Summary: Neuroblastoma (NB) accounts for 15% of all cancer related deaths of children. While amplification of the Myc-N proto-oncogene (MYCN) is a major driver of NB, expression of the neurotrophin receptor, NTRK1/TrkA, has been shown to associate with an excellent outcome. MYCN down-regulate...
ORGANISM(S): Homo sapiens (Human) 
2021-11-11 | PXD026913 | Pride
Neuroblastoma Mycn Nuclear foci Trka Ntrk1 
GenomicsTargeting NTRK1 Enhances Immune Checkpoint Inhibitor Efficacy in NTRK1 Wild-type Non-Small Cell Lung Cancer
Targeting NTRK1 Enhances Immune Checkpoint Inhibitor Efficacy in NTRK1 Wild-type Non-Small Cell Lung Cancer
PRJNA1148643 | ENA
TranscriptomicsTargeting NTRK1 Enhances Immune Checkpoint Inhibitor Efficacy in NTRK1 Wild-type Non-Small Cell Lung Cancer
Treatment of non-small cell lung cancer (NSCLC) has drastically changed in recent years owing to the robust anti-cancer effects of immune-checkpoint inhibitors (ICI). However, only 20% of NSCLC patients benefit from ICIs, highlighting the need to uncover the mechanisms mediating resistance. By analy...
ORGANISM(S): Mus musculus 
2024-08-20 | GSE274960 | GEO
GenomicsNTRK1 fusions for the therapeutic intervention of Korean patients with colon cancer
NTRK1 fusions for the therapeutic intervention of Korean patients with colon cancer
PRJNA748264 | ENA
TranscriptomicsNTRK1 fusions for the therapeutic intervention of Korean patients with colon cancer
The identification and clinical validation of cancer driver genes are essential to accelerate the translational transition of cancer genomics, as well as to find clinically confident targets for the therapeutic intervention of cancers. Here we identified recurrent LMNA-NTRK1 and TPM3-NTRK1 fusions i...
ORGANISM(S): Homo sapiens 
2021-07-31 | GSE180440 | GEO
UnknownTargeting NTRK1 Enhances Immune Checkpoint Inhibitor Efficacy in NTRK1 Wild-Type Non-Small Cell Lung Cancer.
Not available
S-EPMC11611666 | biostudies-literature
UnknownNTRK1 fusion in glioblastoma multiforme.
Not available
S-EPMC3960150 | biostudies-literature
TranscriptomicsEZH2 regulates neuroblastoma cell differentiation via NTRK1 promoter epigenetic modifications
The polycomb repressor complex 2 molecule EZH2 is now known to play a role in essential cellular processes, namely, cell fate decisions, cell cycle regulation, senescence, cell differentiation, and cancer development/progression. EZH2 inhibitors have recently been developed; however, their effective...
ORGANISM(S): Homo sapiens 
2018-05-01 | GSE98642 | GEO
GenomicsTranscriptomics reveals the effects of NTRK1 on endoplasmic reticulum stress response-associated genes in human neuronal cell lines
Transcriptomics reveals the effects of NTRK1 on endoplasmic reticulum stress response-associated genes in human neuronal cell lines
PRJNA912623 | ENA
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