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MetabolomicsMuscle metabolic resilience and enhanced exercise adaptation by Esr1-induced remodeling of mitochondrial cristae-nucleoid architecture in males

Reduced estrogen action is associated with obesity and insulin resistance. However, the cell and tissue-specific actions of estradiol in maintaining metabolic health remain inadequately understood, especially in men. We observed that skeletal muscle ESR1/Esr1 (encodes estrogen receptor α) is posi...

2025-04-09 | MTBLS914 | MetaboLights
TranscriptomicsNuclear scaffold and matrix attachment of HeLa chromatin
The nuclear scaffold/matrix provides an anchor for higher order genome structure that has both structural and functional implications. Different extraction protocols, i.e., utilizing either 25 mM LIS or 2 M NaCl, isolate somewhat different protein constituents of either the nuclear scaffold or nucl...
ORGANISM(S): Homo sapiens 
2010-05-22 | E-GEOD-13774 | biostudies-arrayexpress
ProteomicsIdentification of evolutionarily conserved nuclear matrix proteins and their prokaryotic origins
Compared to prokaryotic cells, a typical eukaryotic cell is much more complex along with its endomembrane system and membrane-bound organelles. Although the endosymbiosis theories convincingly explain the evolution of membrane-bound organelles such as mitochondria and chloroplasts, very little is un...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) Drosophila melanogaster (Fruit fly) 
2021-01-26 | PXD012926 | Pride
Core nuclear matrix proteome Nuclear evolution Nuclear matrix Nucleoskeleton Nuclear architecture 
ProteomicsComparison of Nuclear Matrix and Mitotic Chromosome Scaffold proteins in Drosophila S2 cells – Transmission of hallmarks of nuclear organization through mitosis
During open mitosis chromatin condenses to form chromosomes and decondenses post-mitotically to re-occupy their designated nuclear territory in a precisely lineage specific manner. This necessitates that features of nuclear architecture persist through mitosis. Here we present a proteomic study, whi...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2018-07-17 | PXD008404 | Pride
Nuclear matrix Drosophila melanogastor S2 cells Nuclear architecture Mitotic chromosome scaffold Mitosis 
TranscriptomicsThe Nucleosome Landscape of P. falciparum Reveals Chromatin Architecture and Dynamics of Regulatory Sequences
In eukaryotes, the chromatin architecture has a pivotal role in regulating all DNA-related processes. For P. falciparum, the causative agent of human malaria, the nucleosome landscape of the extremely AT-rich intergenic regulatory regions is largely unexplored. With the aid of a highly controlled MN...
ORGANISM(S): Plasmodium falciparum 
2015-11-25 | E-GEOD-66185 | biostudies-arrayexpress
TranscriptomicsTranscriptomic and nuclear architecture of immune cells after LPS-activation
Changes in the nuclear positioning of specific genes, depending on their expression status, have been observed in a large diversity of physiological processes. However, gene position is poorly documented in immune cells subjected to activation upon bacterial infection. Using the pig as a model organ...
ORGANISM(S): Sus scrofa 
2011-11-02 | E-GEOD-25491 | biostudies-arrayexpress
ProteomicsLamin A acetylation shapes nuclear architecture and safeguards genomic integrity
The nuclear lamina constitutes more than a structural scaffold for the nucleus and plays a crucial role in protection of genomic integrity. Here we report that the loss of the lysine acetyl-transferase (KAT) MOF leads to nuclear architecture defects during interphase including micronuclei formation....
ORGANISM(S): Mus musculus (Mouse) 
2019-08-16 | PXD008539 | Pride
Acetylation Mouse Qexactive Lc-msms 
GenomicsDynamic reorganization of nuclear architecture during human cardiogenesis [HiC-seq]
Dynamic reorganization of nuclear architecture during human cardiogenesis [HiC-seq]
PRJNA417685 | ENA
GenomicsDynamic reorganization of nuclear architecture during human cardiogenesis [RNA-seq]
Dynamic reorganization of nuclear architecture during human cardiogenesis [RNA-seq]
PRJNA417683 | ENA
GenomicsDynamic reorganization of nuclear architecture during human cardiogenesis [ATAC-seq]
Dynamic reorganization of nuclear architecture during human cardiogenesis [ATAC-seq]
PRJNA417684 | ENA
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