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ProteomicsContribution of IFIX to nuclear and cytoplasmic proteome changes during immune signaling
IFIX is a nuclear DNA sensor that is known to induce cytokine expression in response to both cytoplasmic DNA and foreign DNA in the nucleus. Here, we examine the concomitant nuclear and cytoplasmic proteome changes that are driven by IFIX during immune response to viral infection and transfection of...
ORGANISM(S): Homo sapiens (Human) Human alphaherpesvirus 1 
2021-06-02 | PXD025101 | Pride
Nuclear dna sensor Ptm Innate immunity Ifix 
OtherThe functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA.
Data from ProteomeXchange, PXD ID: PXD001572. File: 2012_07_03_IFIXGFP_PD13.mzml. Published as part of . From the Abstract: {{i}} he human PYHIN proteins, AIM2, IFI16, IFIX, and MNDA, are critical regulators of immune response, transcription, apoptosis, and cell cycle. However, their protein intera...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32310018443 | GPMDB
Resource Reanalysis 
TranscriptomicsConserved nutrient sensor O-GlcNAc transferase is integral to the C. elegans pathogen-specific immune response
Discriminating pathogenic bacteria from energy-harvesting commensals is key to host immunity. Using mutants defective in the enzymes of O-linked N-acetylglucosamine (O-GlcNAc) cycling, we examined the role of this nutrient-sensing pathway in the Caenorhabidits elegans innate immune response. Using w...
ORGANISM(S): Caenorhabditis elegans 
2015-05-01 | E-GEOD-53732 | biostudies-arrayexpress
TranscriptomicsKu70 Is a Novel Cytosolic DNA Sensor that Induces Type-III Rather than Type-I IFN
Cytosolic foreign DNA is detected by pattern recognition receptors and mainly induces Type-I IFN production. We found that transfection of different types of DNA into various untreated cells induces Type-III IFN (IFN-lambda1) rather than Type-I IFN, indicating the presence of uncharacterized DNA sen...
ORGANISM(S): Homo sapiens 
2011-01-29 | E-GEOD-26944 | biostudies-arrayexpress
Proteomics,MultiomicsInteractome analysis of PYHIN immune regulators
The human PYHIN proteins, AIM2, IFI16, IFIX, and MNDA, are regulators of immune response, transcription, apoptosis, and cell cycle. However, their protein interactions and underlying mechanisms remain largely uncharacterized. Here, we provide the interaction network for all PYHIN proteins. By design...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-20 | MSV000079955 | MassIVE
UnknownThe Nuclear DNA Sensor IFI16 Indiscriminately Binds to and Diminishes Accessibility of the HSV-1 Genome to Suppress Infection.
Not available
S-EPMC9239196 | biostudies-literature
UnknownNuclear soluble cGAS senses double-stranded DNA virus infection.
Not available
S-EPMC9090744 | biostudies-literature
TranscriptomicsKu70 Is a Novel Cytosolic DNA Sensor that Induces Type-III Rather than Type-I IFN
Cytosolic foreign DNA is detected by pattern recognition receptors and mainly induces Type-I IFN production. We found that transfection of different types of DNA into various untreated cells induces Type-III IFN (IFN-lambda1) rather than Type-I IFN, indicating the presence of uncharacterized DNA sen...
ORGANISM(S): Homo sapiens 
2011-01-29 | GSE26944 | GEO
ProteomicsPyrin oligomerization nucleates antiviral IFI16 sensing of herpesvirus DNA
The formation of multimerized protein assemblies has emerged as a core component of immune signal amplification, yet the biochemical basis of this phenomenon remains unclear for many mammalian proteins within host defense pathways. The interferon-inducible protein 16 (IFI16) is a viral DNA sensor th...
ORGANISM(S): Homo sapiens (Human) 
2019-07-10 | PXD014349 | Pride
Ifi16 Ip-ms Dna sensing Hsv-1 Oligomerization 
TranscriptomicsEffect of carbon monoxide and the CO sensor CooA on gene expression in Desulfovibrio vulgaris Hildenborough
Investigating the role of carbon monoxide and a CO sensor protein CooA in the physiology of Desulfovibrio vulgaris Hildenborough using whole genome expression analysis Comparison of whole genome expression changes in the wild type and a strain deleted for CooA (DVU2097) in the presence and absence o...
ORGANISM(S): Desulfovibrio vulgaris str. Hildenborough 
2012-07-30 | E-GEOD-36770 | biostudies-arrayexpress
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