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TranscriptomicsCytoplasmic Assembly and Selective Nuclear Import of Arabidopsis ARGONAUTE4/siRNA Complexes
Here we profiled small RNAs from whole cell, cytoplasmic and nuclear extracts from three-week-old Arabidopsis seedlings. We unexpectedly found that nuclear functional hc-siRNAs are predominantly present in the cytoplasm. Samples from Arabidopsis thaliana whole cell, cytoplasmic and nuclear extract...
ORGANISM(S): Arabidopsis thaliana 
2012-07-12 | E-GEOD-36500 | biostudies-arrayexpress
MetabolomicsTFAM loss induces nuclear actin assembly upon mDia2 malonylation to promote liver cancer metastasis
The mechanisms underlying cancer metastasis remain poorly understood. Here, we report that TFAM deficiency rapidly and stably induced spontaneous lung metastasis in mice with liver cancer. Interestingly, unexpected polymerization of nuclear actin was observed in TFAM-knockdown HCC cells when cytoske...
2022-06-23 | MTBLS4307 | MetaboLights
TranscriptomicsThe ß-importin KAP8 (Pse1/Kap121) is required for nuclear import of the cellulase transcriptional regulator XYR1, asexual sporulation and stress resistance in Trichoderma reesei
The ascomycete Trichoderma reesei is an industrial producer of cellulolytic and hemicellulolytic enzymes and also serves as a model for investigations on these enzymes and their genes. Most of them are obligatorily dependent on the Zn(II)Cys(VI) transcriptional activator XYR1. XYR1 is constitutively...
ORGANISM(S): Trichoderma reesei 
2015-03-03 | E-GEOD-59600 | biostudies-arrayexpress
ProteomicsDifferential nuclear import sets the timing of protein access to the embryonic genome
During early embryonic cell divisions, the total nuclear volume doubles with each cycle. At a critical volume ratio between the nucleus and cytoplasm, embryos start transcribing their genome in a reproducible and sequential manner. However, the underlying molecular mechanism for these well-timed eve...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2022-08-30 | PXD028069 | Pride
Multiplexed quantitative proteomics Lc-ms Xenopus embryo Nucleocytoplasmic partitioning Zygotic gene activation Early embryogenesis Nuclear import 
ProteomicsDifferential nuclear import sets the timing of protein access to the embryonic genome
During early embryonic cell divisions, the total nuclear volume doubles with each cycle. At a critical volume ratio between the nucleus and cytoplasm, embryos start transcribing their genome in a reproducible and sequential manner. However, the underlying molecular mechanism for these well-timed eve...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2022-08-30 | PXD036403 | Pride
Multiplexed quantitative proteomics Lc-ms Xenopus embryo Nucleocytoplasmic partitioning Zygotic gene activation Early embryogenesis Nuclear import 
TranscriptomicsIwr1 directs RNA polymerase II nuclear import
Effect of the deletion of IWR1 (YDL115c) on the Saccharomyces cerevisiae transcriptome
ORGANISM(S): Saccharomyces cerevisiae 
2011-03-23 | E-MEXP-3126 | biostudies-arrayexpress
ProteomicsNEAT1 Regulates BMSCs Aging Through Disruption of FGF2 Nuclear Transport
Background: The aging of bone marrow mesenchymal stem cells (BMSCs) impairs bone tissue regeneration, contributing to skeletal disorders. LncRNA NEAT1 is considered as a proliferative inhibitory role during cellular senescence, but the relevant mechanisms remain insufficient. This study aims to eluc...
ORGANISM(S): Homo Sapiens 
2025-01-16 | PXD059860 |
ProteomicsTransportin 1 is a major nuclear import receptor of the nitric oxide synthase interacting protein
The nitric oxide synthase interacting protein (NOSIP), an E3-ubiquitin ligase, is involved in various processes like neuronal development, craniofacial development, granulopoiesis, mitogenic signaling, apoptosis and cell proliferation. The best characterized function of NOSIP is the regulation of eN...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD033966 | Pride
Transportin Nuclear import 
GenomicsAKIRIN2 controls the nuclear import of proteasomes in vertebrates
AKIRIN2 controls the nuclear import of proteasomes in vertebrates
PRJNA662348 | ENA
ProteomicsTransportin-1 (TRN-1) orchestrates HIV-1 uncoating and nuclear import
Timely uncoating and nuclear import are key to efficient HIV infection, however the triggers and mechanisms that orchestrate these steps are unknown. Here we show that HIV-1 exploits Transportin-1/TRN-1 for both uncoating and nuclear import. Depletion of TRN-1, which we characterised by mass spectro...
ORGANISM(S): Homo sapiens (Human) 
2019-09-25 | PXD010023 | Pride
Trn-1 Co-immunoprecipitation Human Transportin-1 Hiv Nuclear import Orbitrap fusion 
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