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GenomicsTANGO6 coordinates transcription and translation through nucleocytoplasmic partitioning
TANGO6 coordinates transcription and translation through nucleocytoplasmic partitioning
PRJNA1182235 | ENA
GenomicsNeural stem cells alter nucleocytoplasmic partitioning and accumulate nuclear polyadenylated transcripts during quiescence
Neural stem cells alter nucleocytoplasmic partitioning and accumulate nuclear polyadenylated transcripts during quiescence
PRJNA680360 | ENA
TranscriptomicsTANGO6 coordinates transcription and translation through nucleocytoplasmic partitioning
Coordinated RNA and protein synthesis is fundamental to cell function and survival. Here, we show that TANGO6, a nucleocytoplasmic RNA-binding protein, is an integral component of the proteostasis control axis, regulating both transcription and translation. In the nucleus, TANGO6 is recruited to gen...
ORGANISM(S): Homo sapiens 
2026-08-13 | GSE281079 | GEO
TranscriptomicsNeural stem cells alter nucleocytoplasmic partitioning and accumulate nuclear polyadenylated transcripts during quiescence
Quiescence is a cellular state characterized by reversible cell-cycle arrest and diminished biosynthetic activity that protects against environmental insults, replicative exhaustion and proliferation-induced mutations. Entry into and exit from this state controls development, maintenance and repair ...
ORGANISM(S): Mus musculus 
2021-01-05 | GSE162047 | GEO
UnknownA deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.
Not available
S-EPMC4764573 | biostudies-literature
ProteomicsCRM1 Exportome and nucleocytoplasmic partition
CRM1 mediates one of the major nuclear export pathways with the broadest range of cargoes. So far, more than 100 structurally and functionally diverse CRM1 cargoes have been described. We employed affinity purification mass spectrometry for in depth characterization of CRM1 "exportome" in three mode...
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) Xenopus laevis (African clawed frog) 
2016-01-04 | PXD002899 | Pride
Human Xenopus S.cerevisiae 
UnknownLoss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromes.
Not available
S-EPMC5451164 | biostudies-literature
ProteomicsDifferential nuclear import sets the timing of protein access to the embryonic genome
During early embryonic cell divisions, the total nuclear volume doubles with each cycle. At a critical volume ratio between the nucleus and cytoplasm, embryos start transcribing their genome in a reproducible and sequential manner. However, the underlying molecular mechanism for these well-timed eve...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2022-08-30 | PXD028069 | Pride
Multiplexed quantitative proteomics Lc-ms Xenopus embryo Nucleocytoplasmic partitioning Zygotic gene activation Early embryogenesis Nuclear import 
ProteomicsDifferential nuclear import sets the timing of protein access to the embryonic genome
During early embryonic cell divisions, the total nuclear volume doubles with each cycle. At a critical volume ratio between the nucleus and cytoplasm, embryos start transcribing their genome in a reproducible and sequential manner. However, the underlying molecular mechanism for these well-timed eve...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2022-08-30 | PXD036403 | Pride
Multiplexed quantitative proteomics Lc-ms Xenopus embryo Nucleocytoplasmic partitioning Zygotic gene activation Early embryogenesis Nuclear import 
ProteomicsThe Nuclear Proteome of a Vertebrate
Despite the nucleus’ central role in multi-cellular biology, it is still poorly understood how the cell’s proteome is partitioned between the nucleus and cytoplasm. This is mostly due to the difficulty of separating the nuclear and cytoplasmic contents and the challenge to comprehensively measure re...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2015-09-17 | PXD001297 | Pride
Nucleus Tmtc Xenopus Multinotchms3 
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