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ProteomicsCardiovirus-Mediated PKR Inhibition Results from Nucleocytoplasmic Trafficking Disruption
Protein kinase R (PKR) is a key antiviral kinase activated by binding double-stranded RNA (dsRNA) produced during viral replication. Upon activation, PKR phosphorylates eIF2α, leading to the inhibition of translation and viral replication. However, many viruses have evolved mechanisms to counteract ...
ORGANISM(S): Homo sapiens (Human) 
2025-11-17 | PXD066206 | Pride
Nucleocytoplasmic traffic Pkr Nucleocytoplasmic trafficking disorder (nctd) Cardiovirus Stress granules. Picornavirus Nucleoli Double-stranded rna Eif2ak2 
ProteomicsDisruption of nucleocytoplasmic trafficking as a cellular senescence driver
Senescent cells exhibit a reduced response to intrinsic and extrinsic stimuli. This reduction could be explained by disrupted nuclear transmission of signals. However, this hypothesis required more evidence to complete as a new modality of cellular senescence. Proteomic analysis of the cytoplasmic a...
ORGANISM(S): Homo sapiens (Human) 
2021-06-18 | PXD025618 | Pride
Nuclear barrier Cellular senescence Replicative senescence Eukaryotic aging Nucleocytoplasmic trafficking 
UnknownCardiovirus-Mediated PKR inhibition results from nucleocytoplasmic trafficking disruption.
Not available
S-EPMC12747429 | biostudies-literature
UnknownNucleocytoplasmic trafficking and turnover mechanisms of BRASSINAZOLE RESISTANT1 in Arabidopsis thaliana.
Not available
S-EPMC8379927 | biostudies-literature
UnknownThe Ebola Virus Interferon Antagonist VP24 Undergoes Active Nucleocytoplasmic Trafficking.
Not available
S-EPMC8402725 | biostudies-literature
UnknownPhosphorylation by casein kinase 1 regulates tonicity-induced osmotic response element-binding protein/tonicity enhancer-binding protein nucleocytoplasmic trafficking.
Not available
S-EPMC2427355 | biostudies-literature
UnknownCardiovirus Leader proteins bind exportins: Implications for virus replication and nucleocytoplasmic trafficking inhibition.
Not available
S-EPMC4679524 | biostudies-literature
UnknownDisruption of nucleocytoplasmic trafficking as a cellular senescence driver.
Not available
S-EPMC8257587 | biostudies-literature
UnknownHIV-1 Recruits UPF1 but Excludes UPF2 to Promote Nucleocytoplasmic Export of the Genomic RNA.
Not available
S-EPMC4693258 | biostudies-literature
ProteomicsCardioviruses’ leader proteins retarget RSK kinases toward alternative substrates to perturb nucleocytoplasmic traffic
Proteins from unrelated pathogens, including some RNA or DNA viruses and bacteria can recruit and activate cellular p90-ribosomal protein S6 kinases (RSKs) through a common linear motif. Data suggested a model where pathogens' proteins act to dock the recruited RSKs toward specific substrates, which...
ORGANISM(S): Homo sapiens (Human) 
2022-12-08 | PXD034604 | Pride
P90 ribosomal s6 kinases Picornavirus Nucleocytoplasmic traffic Rsk Cardiovirus Phosphorylation Yopm Nucleoporins Linear motifs 
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