Sort   by:  
 Page size 
TranscriptomicsTranscription profiling by high throughput sequencing of methamphetamine-sensitized and saline-control mouse nucleus accumbens
Using ssRNA-seq, we examined the alteration of transcription profiles in the nucleus accumbens of methamphetamine-sensitized mice. Methamphetamine was a commonly abused psychostimulant. Repeated exposure to methamphetamine elicited long-lasting cellular and molecular changes, including the aberrant ...
ORGANISM(S): Mus musculus 
2017-01-15 | E-MTAB-2843 | biostudies-arrayexpress
TranscriptomicsEffects of cocaine and withdrawal on the mouse nucleus accumbens transcriptome.
Genetic association studies, pharmacological investigations and analysis of mice-lacking individual genes have made it clear that Cocaine administration and Withdrawal have a profound impact on multiple neurotransmitter systems. The GABAergic medium spiny neurons of the nucleus accumbens (NAc) exhib...
ORGANISM(S): Mus musculus 
2013-01-10 | E-GEOD-43410 | biostudies-arrayexpress
GenomicsGenome-wide DNA methylation profiling reveals epigenetic changes in the rat nucleus accumbens associated with cross-generational effects of adolescent THC exposure
Drug exposure during critical periods of development is known to have lasting effects, increasing one’s risk for developing mental health disorders. Emerging evidence has also indicated the possibility for drug exposure to even impact subsequent generations. Our previous work demonstrated that adole...
ORGANISM(S): Rattus norvegicus 
2015-06-19 | E-GEOD-69984 | biostudies-arrayexpress
TranscriptomicsTranslational profiling of hypothalamic and midbrain neurons that project to the nucleus accumbens.
Neuroanatomical methods enable high-resolution mapping of neural circuitry, but do not allow systematic molecular profiling of neurons based on their connectivity. Here, we report the development of a novel approach for molecularly profiling projective neurons. We show that ribosomes can be labeled ...
ORGANISM(S): Mus musculus 
2014-05-22 | E-GEOD-55800 | biostudies-arrayexpress
TranscriptomicsGenes associated with alcohol abuse and nicotine addiction in the human nucleus accumbens
Background: The incidence of alcohol and tobacco co-abuse is as high as 80%. The molecular mechanism underlying this comorbidity is virtually unknown but interactions between these drugs have important implications for the development of, and recovery from drug dependence. Methods: We investigat...
ORGANISM(S): Homo sapiens 
2010-07-01 | E-GEOD-20568 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse brain region bed nucleus of the stria terminalis, nucleus accumbens, and dorsal striatum to identify distinct transcriptional patterns.
To identify distinct transcriptional patterns between the major subcortical dopamine targets commonly studied in addiction we studied differences in gene expression between the bed nucleus of the stria terminalis (BNST), nucleus accumbens (NAc), and dorsal striatum (dStr) using microarray analysis. ...
ORGANISM(S): Mus musculus 
2007-11-13 | E-GEOD-5763 | biostudies-arrayexpress
GenomicsBAZ1B in Nucleus Accumbens Regulates Reward-Related Behaviors in Response to Distinct Emotional Stimuli
ATP-dependent chromatin remodeling proteins are being implicated increasingly in the regulation of complex behaviors, including models of several psychiatric disorders. Here, we demonstrate that Baz1b, an accessory subunit of the ISWI family of chromatin remodeling complexes, is upregulated in the n...
ORGANISM(S): Mus musculus 
2016-07-30 | E-GEOD-85005 | biostudies-arrayexpress
TranscriptomicsSex Differences in Nucleus Accumbens Transcriptome Profiles Associated with Susceptibility versus Resilience to Subchronic Variable Stress
Depression and anxiety disorders are more prevalent in females, but the majority of research in animal models, the first step in finding new treatments, has focused predominantly on males. Here we report that exposure to subchronic variable stress (SCVS) induces depression-associated behaviors in fe...
ORGANISM(S): Mus musculus 
2016-08-04 | E-GEOD-85136 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression profile of methamphetamine-sensitized and saline-control mice examined by high throughput sequencing
Using microRNA-Seq, we examined the alteration of microRNA expression profiles in the nucleus accumbens of methamphetamine-sensitized and saline-control mice. Nucleus accumbens lysate from eight mice of each group were pooled as one sample. Two RNA samples from each group were prepared and were then...
ORGANISM(S): Mus musculus 
2022-07-13 | E-MTAB-2901 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat nucleus accumbens of alcohol-preferring animals following chronic ethanol consumption
This study investigated changes in gene expression associated with ethanol drinking in adult male P rats under the following conditions for 8 weeks: continuous access (24 hr/day, 7 days/week), multiple scheduled access (three 1-hr sessions during the dark cycle/day, 5 days/week) and ethanol-naive (w...
ORGANISM(S): Rattus norvegicus 
2009-09-25 | E-GEOD-13524 | biostudies-arrayexpress
Sort   by:  
 Page size