Sort   by:  
 Page size 
Transcriptomicsnumb and numblike deleted by Nkx2.5Cre
The ventricular wall of the heart is composed of trabeculated and compactlayers, which are separated by yet unknown processes during embryonic development. Notch signaling plays important roles in cardiac development. Mutations in Notch signaling components are related to human congenital heart dise...
ORGANISM(S): Mus musculus 
2013-01-17 | E-MEXP-3490 | biostudies-arrayexpress
ProteomicsSeptin 7 Interacts With Numb To Preserve Sarcomere Structural Organization And Muscle Contractile Function
Here, we investigated mechanisms by which aging-related reductions of the levels of Numb in skeletal muscle fibers contribute to loss of muscle strength and power, two critical features of sarcopenia. Numb is an adaptor protein best known for its critical roles in development including asymmetric ce...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-04-28 | MSV000089327 | MassIVE
ProteomicsComprehensive Identification of Phosphorylation Sites on the Numb Endocytic Adaptor Protein
Numb is an endocytic adaptor protein that functions in the endocytosis and intracellular trafficking of membrane receptors and adhesion molecules. Numb localization and function have been shown to be regulated by phosphorylation through atypcial protein kinase C at several key sites. Here, we use ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-04 | MSV000080218 | MassIVE
TranscriptomicsRegulation of NUMB alternative splicing by RBM5, RBM6 and RBM10 controls cancer cell proliferation
RBM5, a regulator of alternative splicing of apoptotic genes, and its close homologues, RBM6 and RBM10, are RNA binding proteins frequently deleted or mutated in lung cancer. We report that RBM5/6 and RBM10 antagonistically regulate the proliferative capacity of cancer cells and display distinct pos...
ORGANISM(S): Homo sapiens 
2013-12-20 | E-GEOD-47431 | biostudies-arrayexpress
TranscriptomicsRegulation of NUMB alternative splicing by RBM5, RBM6 and RBM10 controls cancer cell proliferation (CLIP-Seq)
RBM5, a regulator of alternative splicing of apoptotic genes, and its close homologues, RBM6 and RBM10, are RNA binding proteins frequently deleted or mutated in lung cancer. We report that RBM5/6 and RBM10 antagonistically regulate the proliferative capacity of cancer cells and display distinct pos...
ORGANISM(S): Homo sapiens 
2013-12-20 | E-GEOD-48066 | biostudies-arrayexpress
ProteomicsComprehensive Identification of Phosphorylation Sites on the Numb Endocytic Adaptor Protein
Numb is an endocytic adaptor protein that functions in the endocytosis and intracellular trafficking of membrane receptors and adhesion molecules. Numb localization and function have been shown to be regulated by phosphorylation through atypcial protein kinase C at several key sites. Here, we use ...
ORGANISM(S): Homo sapiens (Human) 
2014-12-16 | PXD000997 | Pride
Numb  phosphorylation  cyclin d kinase 5  mass spectrometry 
TranscriptomicsNumb variant specific transcriptome analysis
Numb has 4 known variants and we are reporting two novel Numb variants, Numb5 and Numb6 in this study. The metastaticability variations between the numb variants were evaluated through the transcriptome. breast cancer cells were transfected with GFP-Numb4, GFP-Numb5, GFP-Numb6 or GFP-only vectors an...
ORGANISM(S): Homo sapiens 
2011-05-09 | E-GEOD-29137 | biostudies-arrayexpress
GenomicsEffects on mRNA levels of a Numb and Numb-like conditional knockout in skeletal muscle fibers
Effects on mRNA levels of a Numb and Numb-like conditional knockout in skeletal muscle fibers
PRJNA704557 | ENA
ProteomicsNUMB isoforms interactome study
HEK293 cells were transfected with NUMB-FLAG isoforms 1,2,3,4. anti-FLAG immunoprecipitationIP of all isoforms plus control sample were loaded on SDS-PAGE gel and CTRL plus ISOform1,2,3,4 lanes upon IP were processed by LC-MSMS analysis.
ORGANISM(S): Homo sapiens (Human) 
2026-06-15 | PXD064868 | Pride
Numb protein mass spectrometry 
TranscriptomicsNumb variant specific transcriptome analysis
Numb has 4 known variants and we are reporting two novel Numb variants, Numb5 and Numb6 in this study. The metastaticability variations between the numb variants were evaulated through the transcriptome.
ORGANISM(S): Homo sapiens 
2011-05-09 | GSE29137 | GEO
Sort   by:  
 Page size