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GenomicsGenomic characterization of NUT midline carcinoma
In this study, we sequenced two NUT midline carcinoma genomes. Analysis of rearrangement breakpoint provided information on the generating event of BRD-NUT rearrangements. Mutational signature analysis also revealed biological process during tumorigenesis of NUT midline carcinomas.
EGAS00001001934 | EGA
TranscriptomicsDifferentiation of NUT midline carcinoma by epigenomic reprogramming
Knockdown of the oncogene, BRD4-NUT, in a rare cancer, termed NUTmidline carcinoma (NMC), results in morphologic features consistent with squamous differentiation. Treatment with the HDAC-inhibitor, TSA, appears to cause the same phenotype. Here, we use gene expression profiling to compare the cha...
ORGANISM(S): Homo sapiens 
2011-07-01 | E-GEOD-18668 | biostudies-arrayexpress
ProteomicsNut interactome in round/elongating spermatids
NUT, nuclear protein in testis is the universal fusion partner of BRD4 in the highly aggressive NUT Midline Carcinoma (NMC), but its physiological function was unknown. Here we show that Nut is exclusively expressed in post-meiotic spermatogenic cells, at the time of genome-wide histone hyperacetyla...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-02 | PXD008727 | Pride
Binding partners Nut Spermiogenesis Nanolc-ms/ms 
GenomicsChip-seq mapping of active chromatin marks in BRD4-NUT and different NMC cells
BRD4-NUT megadomains is an order of magnitude larger than super-enhancer regions and displays a more continuously enriched profile rather than appearing as a cluster of individual peaks. Chip-seq mapping of active chromatin marks in BRD4-NUT and different NMC cells
ORGANISM(S): Homo sapiens 
2015-07-14 | E-GEOD-70870 | biostudies-arrayexpress
TranscriptomicsNSD3-NUT Fusion Oncoprotein in NUT Midline Carcinoma identified in 1221 patient-derived cell line by RNA-seq
Discarded live tumor tissue from a metastatic focus in the patientM-bM-^@M-^Ys lung was collected under institutional review board approval through the NUT midline carcinoma registry (www.NMCRegistry.org). From this tissue the first known NUT-variant cell line, 1221, was established. To determine th...
ORGANISM(S): Homo sapiens 
2014-08-01 | E-GEOD-57222 | biostudies-arrayexpress
ProteomicsOncogenic BRD4-NUT protein interactions
To investigate the mechanism that drives dramatic mistargeting of active chromatin in NUT midline carcinoma, we have identified protein interactions unique to the BRD4-NUT fusion oncoprotein compared to wild type BRD4. Using crosslinking, affinity purification, and mass spectrometry, we identified ...
ORGANISM(S): Homo sapiens (Human) 
2017-04-05 | PXD005786 | Pride
Biotap-xl Znf532-nut Hyperacetylation Topological domains 
GenomicsNUT Carcinoma
NUT Carcinoma
PRJNA744550 | ENA
GenomicsShared PRAME epitopes are T-Cell Targets in NUT Carcinoma
Shared PRAME epitopes are T-Cell Targets in NUT Carcinoma
PRJNA1494203 | ENA
TranscriptomicsIdentification of oral carcinoma miRNA involved in Wnt/b-catenin signaling
MicroRNAs (miRNAs) participate in many biological processes and have emerged as key players in carcinogenesis. In order to identify changes in miRNAs specific for betelquid-associated oral squamous cell carcinoma (OSCC), we investigated the expression profiles of 858 miRNAs in a panel of 40 pairs of...
ORGANISM(S): Homo sapiens 
2015-01-07 | E-GEOD-45238 | biostudies-arrayexpress
GenomicsCell state-dependent chromatin targeting in NUT carcinoma
Cell state-dependent chromatin targeting in NUT carcinoma
PRJNA954877 | ENA
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