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TranscriptomicsRole of areca nut induced TGF-β and epithelial mesenchymal interaction in pathogenesis of precancerous Oral submucous fibrosis
To understand the role of areca nut and TGF-β induced gene expression changes in fibroblasts and its contibution in the manifestation of Oral submucous fibrosis, we studied gene expression profile in primary human gingival fibroblast (hGF) cells following treatment with areca nut, TGF-β and both tog...
ORGANISM(S): Homo sapiens 
2015-07-06 | E-GEOD-59414 | biostudies-arrayexpress
TranscriptomicsActivation of TGF-beta pathway by areca nut constituents: A possible cause of Oral submucous fibrosis.
To understand the role of areca nut constituents in manifestation of Oral submucous fibrosis, we studied gene expression profile in epithelial cells following areca nut water extract treatment. A comaprison with TGF-beta induced gene expression changes were performed as epithelial cells were predict...
ORGANISM(S): Homo sapiens 
2013-05-22 | E-GEOD-38227 | biostudies-arrayexpress
ProteomicsA label-free shotgun proteomics analysis of macadamia nut
In this study, we present a first proteomic overview of macadamia nut using a label-free shotgun proteomic approach and prediction of their proteins with potential allergenic activity and cross-reactivity via an in silico analysis. The defense response proteins were the most abundant group of protei...
ORGANISM(S): Macadamia 
2020-01-13 | PXD015364 | Pride
Macadamia nut  label-free shotgun proteomics  in silico analysis  allergenicity  cross-reactivity 
GenomicsGenomic characterization of NUT midline carcinoma
In this study, we sequenced two NUT midline carcinoma genomes. Analysis of rearrangement breakpoint provided information on the generating event of BRD-NUT rearrangements. Mutational signature analysis also revealed biological process during tumorigenesis of NUT midline carcinomas.
EGAS00001001934 | EGA
ProteomicsNut interactome in round/elongating spermatids
NUT, nuclear protein in testis is the universal fusion partner of BRD4 in the highly aggressive NUT Midline Carcinoma (NMC), but its physiological function was unknown. Here we show that Nut is exclusively expressed in post-meiotic spermatogenic cells, at the time of genome-wide histone hyperacetyla...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-02 | PXD008727 | Pride
Binding partners Nut Spermiogenesis Nanolc-ms/ms 
GenomicsChip-seq mapping of active chromatin marks in BRD4-NUT and different NMC cells
BRD4-NUT megadomains is an order of magnitude larger than super-enhancer regions and displays a more continuously enriched profile rather than appearing as a cluster of individual peaks. Chip-seq mapping of active chromatin marks in BRD4-NUT and different NMC cells
ORGANISM(S): Homo sapiens 
2015-07-14 | E-GEOD-70870 | biostudies-arrayexpress
TranscriptomicsDifferentiation of NUT midline carcinoma by epigenomic reprogramming
Knockdown of the oncogene, BRD4-NUT, in a rare cancer, termed NUTmidline carcinoma (NMC), results in morphologic features consistent with squamous differentiation. Treatment with the HDAC-inhibitor, TSA, appears to cause the same phenotype. Here, we use gene expression profiling to compare the cha...
ORGANISM(S): Homo sapiens 
2011-07-01 | E-GEOD-18668 | biostudies-arrayexpress
ProteomicsOncogenic BRD4-NUT protein interactions
To investigate the mechanism that drives dramatic mistargeting of active chromatin in NUT midline carcinoma, we have identified protein interactions unique to the BRD4-NUT fusion oncoprotein compared to wild type BRD4. Using crosslinking, affinity purification, and mass spectrometry, we identified ...
ORGANISM(S): Homo sapiens (Human) 
2017-04-05 | PXD005786 | Pride
Biotap-xl Znf532-nut Hyperacetylation Topological domains 
TranscriptomicsNSD3-NUT Fusion Oncoprotein in NUT Midline Carcinoma identified in 1221 patient-derived cell line by RNA-seq
Discarded live tumor tissue from a metastatic focus in the patientM-bM-^@M-^Ys lung was collected under institutional review board approval through the NUT midline carcinoma registry (www.NMCRegistry.org). From this tissue the first known NUT-variant cell line, 1221, was established. To determine th...
ORGANISM(S): Homo sapiens 
2014-08-01 | E-GEOD-57222 | biostudies-arrayexpress
ProteomicsDevelopment and application of mass spectrometric molecular networking for analyzing ingredients of areca nut
Areca nut(Areca catechu L.) is commonly consumed as a chewing food in the Asian region. However, the investigations into the components of areca nut are limited. In this study, we have developed an approach that combines mass spectrometry with feature-based molecular network to explore the chemical ...
ORGANISM(S): Areca Triandra (ncbitaxon:115441) 
2023-11-10 | MSV000093351 | MassIVE
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