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ProteomicsMistranslation from endogenous tRNA variants in human pan-genome cell lines
Errors in protein synthesis are thought to be rare, yet cells representing the diversity of life tolerate greatly elevated levels of error. One source of translation error in humans are anticodon mutations in transfer RNAs (tRNAs). We found a tRNA Ser AGA -2-3 variant (G35A) that occurs in 2% of the...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD064886 | Pride
Mistranslation Trna variants Translation error 
ProteomicsAspirin Acetylates Thioredoxin Reductase 1 (isoform 4)
Thioredoxin Reductase 1 (isoform 4) was incubated with aspirin for 1 hour at 37 C followed by SDS PAGE. Samples were picked from SDS PAGE gel, digested with trypsin, and sent for LC-MS/MS.
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD027882 | Pride
Thioredoxin reductase Acetylation Aspirin 
ProteomicsFormation and persistence of polyglutamine aggregates in mistranslating cells
In neurodegenerative diseases, including pathologies with well-known causative alleles, genetic factors that modify severity or age of onset are not entirely understood. We recently documented the unexpected prevalence of transfer RNA (tRNA) mutants in the human population, including variants that c...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD027837 | Pride
Trna Amino acid misincorporation Mistranslation 
ProteomicsPerserverence of protein homeostasis despite mistranslation of glycine codons with alanine
By physically linking amino acids to their codon assignments, transfer RNAs (tRNAs) are essential for protein synthesis and translation fidelity. Some natural human tRNA variants cause amino acid mis-incorporation at a codon or set of codons. Recent work showed a naturally occurring tRNASer variant ...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-21 | PXD034180 | Pride
Trna Amino acid misincorporation Mistranslation 
ProteomicsNatural human tRNAAla anticodon variants mistranslate the genetic code
Transfer RNAs (tRNAs) play an essential role in protein synthesis by linking the nucleic acid sequences of gene products to the amino acid sequences of proteins. Although only 32 tRNAs are needed to decode all 61 sense codons in the genetic code, there are > 400 functional tRNA genes in the humans. ...
ORGANISM(S): Homo sapiens (Human) 
2025-03-07 | PXD053463 | Pride
Anticodon Transfer rna Alanine Mistranslation Missense suppression Protein synthesis 
ProteomicsHuman tRNA genes enable differential nonsense suppression in live cells and a model of frontotemporal dementia
Nonsense mutations generate premature termination codons (PTCs) that are responsible for 11% of human genetic disease alleles. Thus, nonsense suppressor tRNAs have broad therapeutic potential. Humans encode > 600 tRNA genes with many identical or similar copies of each tRNA. We hypothesized that tRN...
ORGANISM(S): Homo sapiens (Human) 
2025-07-25 | PXD056053 | Pride
Therapeutics Live-cell fluorescent reporters Frontotemporal dementia Trna Nonsense suppression Progranulin Protein synthesis 
UnknownEarly sedation with dexmedetomidine in ventilated critically ill patients and heterogeneity of treatment effect in the SPICE III randomised controlled trial.
Not available
S-EPMC7939103 | biostudies-literature
UnknownFluid Optimisation in Emergency Laparotomy (FLO-ELA) Trial: study protocol for a multi-centre randomised trial of cardiac output-guided fluid therapy compared to usual care in patients undergoing major emergency gastrointestinal surgery.
Not available
S-EPMC10163929 | biostudies-literature
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