Sort   by:  
 Page size 
MetabolomicsSodium Butyrate mediates Histone Crotonylation and Alleviated Neonatal Rats Hypoxic-Ischemic Brain Injury Through Gut-Brain Axis (untargeted fecal metabolomics)

Neonatal hypoxic-ischemic encephalopathy (HIE) refers to nervous system damage caused by perinatal hypoxia, which is the major cause of long-term neuro-developmental disorders in surviving infants. However, the mechanisms still require further investigation. In this study, we found that the butan...

2022-10-12 | MTBLS4932 | MetaboLights
ProteomicsMicrowave oven-assisted derivatization of histone proteoforms using trimethylacetic anhydride
We introduce a new reagent – Trimethylacetic anhydride (TMA) for highly efficient histone derivatization, which is facilitated by microwave irradiation to reduce sample preparation duration. The derivatization of unmodified NH2- groups at histone lysine residues is necessary prior LC-MS analysis usi...
ORGANISM(S): Homo sapiens (Human) 
2021-06-14 | PXD019502 | Pride
O histone derivatization Epigenetics Mass spectrometry Trimethylacetic anhydride 
ProteomicsIdentification of Khib substrates of histone regulated by NAT10
Having established NAT10’s regulatory role in lysine 2-hydroxyisobutyrylation, we aimed to identify the histone Khib sites targetedby NAT10. To this end, we extracted and digested core histones from cells with or without NAT10 depletion, followed by chemical derivatization of amine groups. The resul...
ORGANISM(S): Homo sapiens (Human) 
2026-01-27 | PXD066039 | Pride
Human liver cancer histone hplc-ms/ms 
ProteomicsUnraveling epigenetic changes in A. thaliana calli: Impact of HDAC inhibitors
The aim was to characterize epigenetic changes in histone proteins during callus formation from roots and shoots of Arabidopsis thaliana seedlings using mass spectrometry-based approach. Increased level of histone H3.3 variant was found to be the most prominent feature of 20-day-old calli, associate...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2024-01-26 | PXD046788 | Pride
Arabidopsis thaliana  callus formation  epigenetics  histone posttranslational modifications  mass spectrometry  trichostatin a  sodium butyrate 
ProteomicsDissection of TET1 catalytic and non-catalytic functions reveals DNA demethylation independent gene and ERV regulation
Surveillance of DNA methylation in mammals is critical for genome stability and epigenetic regulation. The discovery of the ten-eleven translocation (TET) proteins catalyzing the oxidation from 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-11 | PXD028566 | Pride
Methylation Acetylation Tet1 Histone ptms 
ProteomicsTargeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer
Cyclin-Dependent Kinase 9 (CDK9) as part of the PTEFb complex promotes transcriptional elongation by promoting RNAPII pause release. We now report that, paradoxically, CDK9 is also essential for maintaining gene silencing at heterochromatic loci. Through a live cell screen, we discovered that CDK9 i...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-26 | PXD007925 | Pride
Cdk9 Epigenetic therapy Immunosensitization Gene silencing 
MetabolomicsIntergenerational Association of Gut Microbiota and Metabolism with Perinatal Folate Metabolism and Neural Tube Defects (Brain tissue metabolomics)

Neonatal hypoxic-ischemic encephalopathy (HIE) refers to nervous system damage caused by perinatal hypoxia, which is the major cause of long-term neuro-developmental disorders in surviving infants. However, the mechanisms still require further investigation. In this study, we found that the butan...

2022-12-05 | MTBLS4894 | MetaboLights
UnknownActivation of Sirtuin 2 Inhibitors Employing Photoswitchable Geometry and Aqueous Solubility.
Not available
S-EPMC7496931 | biostudies-literature
Sort   by:  
 Page size