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TranscriptomicsMulti-tissue, selective PPARγ modulation of insulin sensitivity and metabolic pathways in obese rats
We characterized the insulin sensitivity and multi-tissue gene expression profiles of lean and insulin resistant, obese Zucker rats untreated or treated with one of four PPARγ ligands (pioglitazone, rosiglitazone, troglitazone, and AG035029). We analyzed the transcriptional profiles of adipose tissu...
ORGANISM(S): Rattus norvegicus 
2011-02-11 | E-GEOD-21329 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of soleus muscle from lean and obese Zucker rats following exercise training
Endurance exercise training has been shown to decrease whole-body and skeletal muscle insulin resistance and increase glucose tolerance in conditions of both pre-diabetes and overt type 2 diabetes. However, the adaptive responses in skeletal muscle at the molecular and genetic level for these benef...
ORGANISM(S): Rattus norvegicus 
2009-11-16 | E-TABM-213 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of hepatocyes from Zucker fa/fa obese rats vs controls
Analysis of the gene signature of steatosis associated to obesity in hepatocytes of Zucker fa/fa obese rats and their controls; identifying target genes linked to steatosis progression. or Obesity and insulin resistance-associated steatosis can be a non-inflammatory condition affecting hepatocytes o...
ORGANISM(S): Rattus norvegicus 
2008-07-31 | E-MEXP-1414 | biostudies-arrayexpress
TranscriptomicsExpression data from liver of WNIN/Ob lean and obese rats
Obesity is risk factor for development of fatty liver. Analysis of altered gene expression gives better understading about the mechanisms involved/alterted in the development of obesity-induced fattyliver in this new obese rat model. We used Microarrays to delinate the alted gene expression in live...
ORGANISM(S): Rattus norvegicus 
2014-06-18 | E-GEOD-58576 | biostudies-arrayexpress
TranscriptomicsExpression data from adipose tissue of WNIN/Ob lean and obese rats
Obesity is characterised by increased adipocyte size and number. Analysis of altered gene expression gives better understading about the mechanisms involved/alterted in the development of obesity in this new obese rat model. We used Microarrays to delinate the alted gene expression in adipose tissue...
ORGANISM(S): Rattus norvegicus 
2014-06-18 | E-GEOD-58575 | biostudies-arrayexpress
MetabolomicsNuclear Magnetic Resonance-Based Blood Metabolic Profiles of Rats Exposed to Short-Term Caloric Restriction
Caloric restriction increases life-span of a number of organisms. The relationship between the increase in life-span and the extent of caloric restriction, however, varies among species. The underlying mechanisms are yet unknown, but appear to be related to changes in metabolism. In order to investi...
2014-09-05 | MTBLS114 | MetaboLights
MetabolomicsDeletion of glycerol channel aquaporin-9 (Aqp9) impairs long-term blood glucose control in C57BL/6 leptin receptor-deficient (db/db) obese mice
Deletion of the glycerol channel aquaporin-9 (Aqp9) reduces postprandial blood glucose levels in leptin receptor deficient (db/db) obese mice on a C57BL/6×C57BLKS mixed genetic background. Furthermore, shRNA mediated reduction of Aqp9 expression reduces liver triacylglycerol (TAG) accumulation in a ...
2015-09-28 | MTBLS219 | MetaboLights
Proteomicscardiac proteomics in obese rats
Cardiac proteome analysis of obese rats treated with mitoQ
ORGANISM(S): Rattus Rattus (black Rat) 
2023-06-29 | PXD034955 | JPOST Repository
TranscriptomicsTranscription profiling of rat epididymal fat tissues from diet induced obesity model against lean controls
Analysis of gene expression profiles of epididymal fat from DIO rats; We applied a comparative functional genomics approach to evaluate diet-induced obese (DIO) rats as an obesity model Experiment Overall Design: Gene expression profiles from DIO and lean rats were generated and compared. A private ...
ORGANISM(S): Rattus norvegicus 
2009-04-23 | E-GEOD-8700 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rats subjected to Roux-en-Y gastruc bypass to characterize of weight loss and weight regain mechanisms
Roux-en-Y gastric bypass (RYGB) is the most effective therapy for morbid obesity, but it has a ~20% failure rate. We used our established RYGB model in diet-induced obese (DIO) Sprague-Dawley rats, which reproduces human bi-phasic body weight (BW) loss pattern, to determine mechanisms contributing t...
ORGANISM(S): Rattus norvegicus 
2008-06-16 | E-GEOD-8314 | biostudies-arrayexpress
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