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ProteomicsSenolytic-Facilitated Reversal of End-Organ Dysfunction in a Murine Model of Obstructive Sleep Apnea
Rationale: Obstructive sleep apnea (OSA) is a highly prevalent condition that is associated with accelerated biological aging and multiple end-organ morbidities. Current treatments, such as continuous positive airway pressure (CPAP), have shown limited cognitive, metabolic, and cardiovascular benefi...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD046854 | Pride
Normoxia Sleep apnea Intermittent hypoxia Senescence 
TranscriptomicsEpigenome analysis of peripheral blood mononuclear cell (PBMC) samples from obstructive sleep apnea patients and healthy subjects
Genome wide DNA methylation profiling of obstructive sleep apnea (OSA) patients and healthy subjects. The Illumina Infinium 27k Human DNA methylation Beadchip v1.2 was used to obtain DNA methylation profiles across approximately 27,000 CpGs in peripheral blood mononuclear cell samples. Samples inclu...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-61463 | biostudies-arrayexpress
ProteomicsSerum proteomic analysis by tandem mass tags-based quantitative proteomics in pediatric obstructive sleep apnea
Pediatric obstructive sleep apnea (OSA) is a frequent respiratory disorder with an estimated prevalence of 3–6% in the general population. However, the underlying pathophysiology of OSA remains unclear. Recently, proteomic analysis using high-resolution and high-throughput mass spectrometry has been...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD032734 | Pride
Obstructive sleep apnea  proteomic analysis  tandem mass tags  differentially expressed proteins  serum  experimental validation 
ProteomicsSalivary Proteomics Research Related to Obstructive Sleep Apnea
The research direction of this project is to analyze the salivary proteome of patients with obstructive sleep apnea.
ORGANISM(S): Homo Sapiens 
2025-04-01 | PXD062443 |
TranscriptomicsVisceral fat trancriptome in obstructive sleep apnea
Rationale: Obstructive sleep apnea (OSA) has been associated with metabolic dysregulation and systemic inflammation. This may be due to pathophysiologic effects of OSA on visceral adipose tissue. We sought to assess the transcriptional consequences of OSA on adipocytes by utilizing pathway-focused a...
ORGANISM(S): Homo sapiens 
2012-09-01 | E-GEOD-38792 | biostudies-arrayexpress
ProteomicsRat atria-2D LC-MS/MS - Atrial electrophysiological and molecular remodelling induced by obstructive sleep apnoea
To understand the molecular change occurring in the atria during obstructive sleep apnea, we have implemented a rat model of OSA involving the surgical implantation of a tracheal obstructive device, allowing the rats to remain conscious and free-roaming throughout 2 weeks of apnea administration. Ra...
ORGANISM(S): Rattus norvegicus (Rat) 
2019-02-21 | PXD011181 | Pride
Rat Protein dysregulations Atria 
TranscriptomicsEpigenomic profiling in visceral white adipose tissue of offspring of mice exposed to late gestational sleep fragmentation
Background: Late gestational sleep fragmentation (LG-SF) is one of the major perturbations associated with sleep apnea and other sleep disorders during pregnancy. Objectives: To investigate the effects of late LG-SF on the epigenome of visceral white adipose tissue (VWAT) in the offspring. Methods: ...
ORGANISM(S): Mus musculus 
2015-04-02 | E-GEOD-63208 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mice treated with hypoxia and/or sleep fragmentation to investigate the hypothesis that intermittent hypoxia may lead to upregulation of some novel peptide(s) that have a powerful glucose lowering action
This study examines the relationship between sleep apnea and glucose metabolism. Physiological studies have demonstrated that 5 days of exposure to intermittent hypoxia (similar to what occurs with sleep apnea) leads to significant improvements in glucose tolerance. Therefore, this study investigat...
ORGANISM(S): Mus musculus 
2007-12-14 | E-GEOD-480 | biostudies-arrayexpress
GenomicsA Randomized Controlled Study of Adenotonsillectomy for Children with Obstructive Sleep Apnea Syndrome (CHAT-BioLINCC)
A Randomized Controlled Study of Adenotonsillectomy for Children with Obstructive Sleep Apnea Syndrome (CHAT-BioLINCC)
PRJNA1419882 | ENA
GenomicsA Randomized Controlled Study of Adenotonsillectomy for Children with Obstructive Sleep Apnea Syndrome (CHAT-BioLINCC)
A Randomized Controlled Study of Adenotonsillectomy for Children with Obstructive Sleep Apnea Syndrome (CHAT-BioLINCC)
PRJNA1419883 | ENA
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