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ProteomicsUltrasonic-based OCT-removal from solid tumor biopsies.
A new method for proteomic studies of OCT-embedded samples based on ultrasound energy is proposed. The cleaning of OCT from mouse kidney embedded tissues were evaluated through the aid of ultrasound energy, with two different frequencies. Simultaneously, vortex agitation was used as control. The opt...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2019-06-13 | PXD013164 | Pride
Oct-embedded samples Ultrasound energy Renal oncocytoma Mass spectrometry. Chromophobe renal cell carcinoma Sample treatment 
ProteomicsMass spectrometry-based quantification of proteins in tumor samples from tissue preserved by different methods – a source of markers of urothelial bladder cancer
Tissue samples in biobanks preserved by formalin-fixation and paraffin-embedding (FFPE) and/or optimal cutting temperature (OCT)-embedded and subsequently freezing are highly valuable in experimental studies where the results can be related to clinical parameters. Today, mass spectrometry (MS)-based...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD020194 | Pride
Formalin-fixed and paraffin-embedded Ffpe Optimal cutting temperature embedded Urinary bladder cancer. Biobank tissue samples Mass spectrometry Proteomics Oct 
ProteomicsActivity-based SWATH/DIA proteomic screen enables sensitive differential detection of serine hydrolases from surgically resected OCT-embedded primary lung adenocarcinoma
Lung malignancies are among the leading causes of cancer-related death in the modern world. While the disease is relatively manageable if caught at an early stage, the genomic variability and high level of mutations represent a daunting challenge for diagnosis, staging and prognostic classification....
ORGANISM(S): Homo sapiens (Human) 
2025-06-02 | PXD019357 | Pride
Abpp Lung adenocarcinoma tissue Swath-ms 
UnknownComparative analysis of differentially abundant proteins quantified by LC-MS/MS between flash frozen and laser microdissected OCT-embedded breast tumor samples.
Not available
S-EPMC7648272 | biostudies-literature
UnknownQuantitative Proteomic Analysis of Optimal Cutting Temperature (OCT) Embedded Core-Needle Biopsy of Lung Cancer.
Not available
S-EPMC5693617 | biostudies-literature
ProteomicsHeat ‘n Beat: A universal high-throughput end-to-end proteomics sample processing platform in under an hour
Clinical proteomics on solid tissue samples from human tumour biopsies present multiple challenges. These include limited sample availability, reducing endogenous protease activity and challenges with efficiently solubilising and digesting proteins for high throughput mass spectrometry while achievi...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2025-03-26 | PXD045405 | Pride
Sample preperation Proteomics High-throughput Heat n beat Universal Mass spec 
TranscriptomicsmiRNA expression profile in leprosy skin biopsy specimens
Skin biopsy specimens of skin lesions were profiled for miRNA expression. In this study, we indentified miRNA species that were differentially expressed in the skin lesions of either the lepromatous or tuberculoid forms of leprosy. One miRNA species, hsa-mir-21, found in the lepromatous lesions was...
ORGANISM(S): Homo sapiens 
2011-12-31 | E-GEOD-33192 | biostudies-arrayexpress
ProteomicsResidual tissue repositories as a resource for population-based cancer proteomic studies
Background Mass spectrometry-based proteomics has become a powerful tool for the identification and quantification of proteins from a wide variety of biological specimens. To date, the majority of studies utilizing tissue samples have been carried out on prospectively collected fresh frozen or optim...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-12-08 | MSV000088548 | MassIVE
TranscriptomicsA high-resolution single-cell multiomic atlas of the human fetal lung - Visium
Fetal lung samples at 12–20 post conception week (pcw) from the HDBR, up to 0.5cm3 in size, were embedded in OCT and flash-frozen in dry-ice cooled isopentane. Twelve-micron cryosections were cut onto Visium slides, haematoxylin and eosin stained and imaged at 20X magnification on a Hamamatsu Nanozo...
ORGANISM(S): Homo sapiens 
2022-01-27 | E-MTAB-11265 | biostudies-arrayexpress
TranscriptomicsProstate Cancer Gene Expression Changes after Treatment with Neoadjuvant Dutasteride
To identify molecular changes underlying the chemopreventive or tumor promoting effects of SRD5A inhibition, we profiled gene expression changes in benign prostate epithelium from patients with PCa treated with dutasteride, a dual SRD5A inhibitor. Subjects were aged 45-80 years with clinically local...
ORGANISM(S): Homo sapiens 
2008-12-01 | E-GEOD-9972 | biostudies-arrayexpress
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