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ProteomicsAMBRA1 controls the translation of immune-specific genes in T lymphocytes
T cell receptor (TCR) engagement causes a global cellular response that entrains signaling pathways, cell cycle regulation, and cell death. The molecular regulation of mRNA translation in these processes is poorly understood. During a whole-genome CRISPR screen for regulators of CD95 (Fas/APO-1)-med...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-10-08 | MSV000096042 | MassIVE
ProteomicsIdentification of potential biomarkers in testicular cancer by SILAC and mass spectrometry
This study represents a proteomic resource for testis cancer with quantitative protein expression data for 5236 proteins. By quantitative mass-spectrometry-based proteomics, we compared the two Malignant germ cell tumour cell lines, TCam-2 with seminoma-like characteristics, and NTERA-2, an embryona...
ORGANISM(S): Homo sapiens (Human) 
2019-11-12 | PXD010275 | Pride
Testis cancer Silac Biomarker 
ProteomicsSHMT2 controls Burkitt lymphoma cell survival by maintaining an oncogenic TCF3 transcriptional program
In this study, the human Burkitt’s Lymphoma cell line BL60 has been analysed via proteomic and phosphoproteomic analysis for effect of a knock down of the serine hydroxymethyltransferase 2 (shSHMT2) compared to a control construct (shGL2). Concerning the phosphoproteome, these results have been comp...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD018961 | Pride
B cell receptor One carbon metabolism Burkitt’s lymphoma 
ProteomicsRHOA Controls Oncogenic B-Cell Receptor Signaling in Aggressive Lymphoma
Diffuse large B cell lymphoma (DLBCL), divided into activated B-cell-like (ABC) and germinal center B-cell-like (GCB), is the most common type of aggressive lymphoma. While many studies have shown treatment response differences based on subtype, recurrently mutated proteins can further alter these r...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2026-01-13 | MSV000100447 | MassIVE
ProteomicsComparative proteomics reveals a diagnostic signature for pulmonary head-and-neck cancer metastasis.
This study represents a proteomic resource for HNSCC and SQCLC with quantitative protein expression data for 7800 proteins and provides a proteomic diagnostic signature for classification for undetermined secondary lung tumors in HNSCC patients. By quantitative mass-spectrometry-based proteomics, we...
ORGANISM(S): Homo sapiens (Human) 
2018-08-06 | PXD007705 | Pride
Head and neck cancer Human tissue proteomics Lung cancer Squamous cell carcinoma Diagnostic biomarker Metastasis 
Transcriptomicsc-MYC target genes in HUVEC
siRNA mediated knock-down of c-MYC vs. scrambled control in human umbilical vein endothelial cells (HUVEC).
ORGANISM(S): Homo sapiens 
2016-01-11 | E-MTAB-4025 | biostudies-arrayexpress
TranscriptomicsFOXO1 target genes in HUVEC
Adenoviral expression of a constitutive active FOXO1 vs. control GFP in human umbilical vein endothelial cells (HUVEC). Expression analysis 16 h after transduction.
ORGANISM(S): Homo sapiens 
2016-01-11 | E-MTAB-4023 | biostudies-arrayexpress
UnknownA multiprotein supercomplex controlling oncogenic signalling in lymphoma.
Not available
S-EPMC6201842 | biostudies-literature
UnknownA pooled analysis of 3 large multicenter trials confirms a survival advantage for NPM1mut AML in MRDneg remission after intensive induction
Not available
S-EPMC12371262 | biostudies-literature
ProteomicsCharacterization of RAS and SLC3A2 signaling in multiple myeloma
Oncogenic mutations within the RAS pathway are common in multiple myeloma (MM), an incurable malignancy of plasma cells. However, the mechanisms of pathogenic RAS signaling in this disease remain enigmatic and difficult to inhibit therapeutically. We employed an unbiased proteogenomic approach to ...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD031662 | Pride
Phosphoproteomes Nras Kras Slc3a2 Bioid2 Multiple myeloma 
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