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UnknownProspective observational study on the pharmacokinetic properties of the Irrua ribavirin regimen used in routine clinical practice in patients with Lassa fever in Nigeria.

Introduction

Lassa fever (LF) is a severe and often fatal systemic disease in humans and affects a large number of countries in West Africa. Treatment options are limited to supportive care and the broad-spectrum antiviral agent ribavirin. However, evidence for ribavirin efficacy in patients...
S-EPMC7200043 | biostudies-literature
UnknownFactors associated with progression to death in patients with Lassa fever in Nigeria: an observational study.

Background

Lassa fever is endemic in several west African countries. Case-fatality rates ranging from 21% to 69% have been reported. The pathophysiology of the disease in humans and determinants of mortality remain poorly understood. We aimed to determine host protein biomarkers capable of d...
S-EPMC8212868 | biostudies-literature
UnknownHigh Burden of Coinfections With Epidemic-Prone Pathogens Among Febrile Patients in Nigeria: A Multi-Pathogen Surveillance Study.

Background

Characterizing the etiology of acute febrile illness (AFI) remains a critical public health priority in malaria-endemic regions such as Nigeria, where constrained diagnostic capacity frequently contributes to misdiagnosis and delays in outbreak detection and response. This study a...
S-EPMC12631764 | biostudies-literature
UnknownEpidemiology of Plasmodium spp. Detection Among Acute Febrile Illness Patients in Two Regions of Nigeria.

Background

Malaria is a common cause of acute febrile illness (AFI) in Nigeria.

Methods

Patients presenting with AFI at two tertiary hospitals were enrolled from August 2023 to September 2024. Specimens were screened for 25 pathogens using a multi-pathogen screening assay. Demographic...
S-EPMC12631765 | biostudies-literature
UnknownDevelopment and evaluation of antibody-capture immunoassays for detection of Lassa virus nucleoprotein-specific immunoglobulin M and G.

Background

The classical method for detection of Lassa virus-specific antibodies is the immunofluorescence assay (IFA) using virus-infected cells as antigen. However, IFA requires laboratories of biosafety level 4 for assay production and an experienced investigator to interpret the fluoresc...
S-EPMC5892945 | biostudies-literature
UnknownDescriptive Epidemiology of Acute Febrile Illness Patients in Nigeria: Pathogens of Global Public Health Significance Detected Using a Multi-Pathogen Detection Tool.

Background

Undifferentiated acute febrile illness (AFI) is a diagnosis that elicits public health concern, as it may be the result of an undiagnosed case of a pathogen of epidemic potential. This study compares the hospital-based incidence and distribution of AFI-causing pathogens in Nigeria...
S-EPMC12631784 | biostudies-literature
UnknownPharmacokinetics of Ribavirin in the Treatment of Lassa Fever: An Observational Clinical Study at the Irrua Specialist Teaching Hospital, Edo State, Nigeria.

Background

Lassa fever is endemic in large parts of West Africa. The recommended antiviral treatment is ribavirin. Two treatment regimens are currently endorsed in Nigeria: the "McCormick regimen" based on a study published in 1986 and the "Irrua regimen" constituting a simplified schedule d...
S-EPMC9907520 | biostudies-literature
UnknownPhylogeography of Lassa Virus in Nigeria.
Lassa virus is genetically diverse with several lineages circulating in West Africa. This study aimed at describing the sequence variability of Lassa virus across Nigeria and inferring its spatiotemporal evolution. We sequenced and isolated 77 Lassa virus strains from 16 Nigerian states. The final d...
S-EPMC6803284 | biostudies-literature
UnknownLassa fever clinical course and setting a standard of care for future randomized trials: A protocol for a cohort study of Lassa-infected patients in Nigeria (LASCOPE).

Background

Lassa Fever (LF), is a severe viral disease prevalent in Western Africa. It is classified as a priority disease by the World Health Organization (WHO). Ribavirin is the recommended therapy despite weak evidence of its efficacy. Promising therapeutic agents are becoming available f...
S-EPMC7616915 | biostudies-literature
UnknownPresentation and Outcomes of Lassa Fever in Children in Nigeria: A Prospective Cohort Study (LASCOPE).

Background

Data on the presentation, management, and outcomes of Lassa fever (LF) in children are limited.

Methods

Description of the clinical and biological features, treatment, and outcomes of reverse transcriptase and polymerase chain reaction (RT-PCR)-confirmed LF in children aged...
S-EPMC11631139 | biostudies-literature
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