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GenomicsDNA-seq of mitochondrial DNA from liver of OGG1 and MUTYH deficient mice that have been bred for five consecutive generations
Studying whether removal of base-excision repair from mitochondria will result into increase in mitochondrial DNA (mtDNA) mutation load. The endogenous genes of OGG1 and MUTYH DNA glycosylases were modified to lack the genomic region encoding for the predicted mitochondrial targeting sequence. The m...
ORGANISM(S): Mus musculus 
2018-07-13 | E-MTAB-6532 | biostudies-arrayexpress
ProteomicsAssessment of CDK4 as a serine kinase phosphorylating OGG1
The early studies showed the serine/threonine of OGG1 was phosphorylated by CDK4 in vitro, in our study, LC-MS/MS was performed, and Byonic engine was used to identify the precise site to be phosphorylated by CDK4.The present study discovered a high basal level of CDK4-mediated phosphorylation of OG...
ORGANISM(S): Homo sapiens (Human) 
2025-04-18 | PXD059565 | Pride
Ogg1 cdk4 phosphorylation 
ProteomicsAssessment of CDK4 as a serine kinase phosphorylating OGG1
The early studies showed the serine/threonine of OGG1 was phosphorylated by CDK4 in vitro, in our study, LC-MS/MS was performed, and Byonic engine was used to identify the precise site to be phosphorylated by CDK4.The present study discovered a high basal level of CDK4-mediated phosphorylation of OG...
ORGANISM(S): Homo sapiens (Human) 
2025-04-18 | PXD059566 | Pride
Ogg1 cdk4 phosphorylation 
Proteomics8-Oxoguanine DNA glycosylase 1 conceals guanine oxidation in nucleoprotein-associated RNA of respiratory syncytial virus
Respiratory syncytial virus (RSV), along with other prominent respiratory RNA viruses such as influenza and SARS-CoV-2, significantly contributes to the global incidence of respiratory tract infections. These pathogens induce the production of reactive oxygen species (ROS), which play a crucial role...
ORGANISM(S): Human respiratory syncytial virus A Homo sapiens (Human) 
2024-10-09 | PXD053262 | Pride
Oxidative stress Ogg1 8-oxoguanine Rna oxidation 
ProteomicsDIA proteomics of OGG1 inhibition in murine model of fibrosis
Interstitial lung diseases such as idiopathic pulmonary fibrosis (IPF) are caused by persistent micro-injuries to alveolar epithelial tissues accompanied by aberrant repair processes. Despite substantial advancement in our understanding of IPF progression, numerous questions remain concerning diseas...
ORGANISM(S): Mus musculus (Mouse) 
2023-02-06 | PXD029625 | Pride
Lung tissue Mus musculus Mass spectrometry Dia-ms Bronchoalveolar lavage fluid Orbitrap 
TranscriptomicsGene expression in chow or HFD-fed OGG1-/- livers
Gene expression in livers of male wild-type (WT) and OGG1-deficient (Ogg1-/-) mice fed either a chow diet or a high-fat diet (HFD) were examined. Mice were fed the diet for 10 weeks prior to tissue collection and were 22 weeks of age at the time of tissue collection. 24 Total samples were analyzed. ...
ORGANISM(S): Mus musculus 
2012-12-16 | E-GEOD-35497 | biostudies-arrayexpress
GenomicsMitochondrial OGG1 expression reduces age-associated neuroinflammation by regulating cytosolic mitochondrial DNA
Mitochondrial OGG1 expression reduces age-associated neuroinflammation by regulating cytosolic mitochondrial DNA
PRJNA945027 | ENA
TranscriptomicsGene expression in chow or HFD-fed OGG1-/- livers
Gene expression in livers of male wild-type (WT) and OGG1-deficient (Ogg1-/-) mice fed either a chow diet or a high-fat diet (HFD) were examined. Mice were fed the diet for 10 weeks prior to tissue collection and were 22 weeks of age at the time of tissue collection.
ORGANISM(S): Mus musculus 
2012-12-16 | GSE35497 | GEO
GenomicsDNA-seq of mitochondrial DNA from mouse heart that is both heart SOD2 knockout and deficient for mitochondrial DNA repair
To study whether increase in mitochondrial oxidative stress (SOD2 removal) and decrease in mitochondrial DNA repair (Ogg1 dMTS) results into increase in mitochondrial DNA mutation load. Oxidative stress has been suggested to induce mutations in mtDNA. To verify this, we extracted and sequenced (Illu...
ORGANISM(S): Mus musculus 
2018-07-13 | E-MTAB-6533 | biostudies-arrayexpress
UnknownOGG1 inhibition suppresses African swine fever virus replication.
Not available
S-EPMC10006199 | biostudies-literature
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