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ProteomicsComprehensive phosphoproteome analysis unravels the core signaling network that initiates the earliest synapse pathology in preclinical Alzheimer's disease brain
Using a high-end mass spectrometry, we screened phosphoproteins and phosphopeptides in four types of Alzheimer's disease (AD) mouse models and human AD postmortem brains. We identified commonly changed phosphoproteins in multiple models and also determined phosphoproteins related to initiation of Ab...
ORGANISM(S): Mus musculus (Mouse) 
2014-09-10 | PXD001292 | Pride
Pkcs Preclinical alzheimer's disease Kinases Signaling network Phosphoproteome Camks 
ProteomicsAD and FTLD model mouse, brain, Phosphoproteome
Using a high-end mass spectrometry, we screened phosphoproteins and phosphopeptides in five types of Alzheimer's disease (AD) mouse models (5xFAD, APP-tg, PS1-tg, PS2-tg and APP-KI) and four types of frontotemporal lobar degeneration (FTLD) mouse models(CHMP2B-KI, PGRN-KI, VCP-KI and TDP43-KI) at m...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-07 | PXD027119 | Pride
Ftld Ad Ftd Mouse Phosphoproteome 
ProteomicsHMGB1 signaling phosphorylates Ku70 and impairs DNA damage repair in Alzheimer’s disease pathology
DNA damage is increased in Alzheimer’s disease (AD), while the underlying mechanisms are unknown. Here, we employ comprehensive phosphoproteome analysis, and identify abnormal phosphorylation of 70 kDa subunit of Ku antigen (Ku70) at Ser77/78, which prevents Ku70-DNA interaction, in human AD postmor...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD028089 | Pride
Hmgb1 Ku70 Phosphorylation Alzheimer's disease 
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