Sort   by:  
 Page size 
ProteomicsFormation of toxic oligomers of polyQ-expanded Huntingtin by prion-mediated cross-seeding
Manifestation of aggregate pathology in Huntington’s disease is thought to be facilitated by a preferential vulnerability of affected brain cells to age-dependent proteostatic decline. To understand how specific cellular backgrounds may facilitate pathologic aggregation, we utilized the yeast model ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-10-21 | PXD031337 | Pride
Aggregation Proteostasis Oligomers Polyq Huntington’s disease Rnq1 Yeast Neurodegeneration Optogenetics Prions 
GenomicsChromosome localization of cohesin oligomers in mid-M arrested yeast cells
Chromosome localization of cohesin oligomers in mid-M arrested yeast cells
PRJNA660294 | ENA
TranscriptomicsTranslatome and transcriptome profiling of SH-SY5Y cells treated with staphylococcal alpha-hemolysin oligomers
Genome-wide analysis of translation has the potential to provide major contributions in understanding the pathophysiology of infection processes, given the complex interplay between pathogens and host cells. This study uncovers the reshaping undergoing in the translational control system of the host...
ORGANISM(S): Homo sapiens 
2015-04-01 | E-GEOD-60543 | biostudies-arrayexpress
ProteomicsGM1 promotes early Aβ oligomer formation and maintenance
The aggregation of amyloid beta (Aβ) peptide is associated with Alzheimer’s disease (AD) pathogenesis. Cell membrane composition, especially monosialotetrahexosylganglioside (GM1), is known to promote the formation of Aβ fibrils, yet little is known about the roles of GM1 in the early steps of Aβ ol...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD029117 | Pride
Oligomers Gm1 Alzheimer's disease Amyloid beta 
GenomicsOptimized design of antisense oligomers for targeted rRNA depletion
Optimized design of antisense oligomers for targeted rRNA depletion
PRJNA640808 | ENA
GenomicsChromosome localization of cohesin oligomers in mid-M arrested yeast cells
We report the genomic localization of cohesin oligomers in nocodazole arrested yeast cells. Two alleles of SMC3 were expressed in yeast cells, one fused to BirA enzyme and the other tagged with AviTag. Cohesin oligomers were biotinylated and ChIP with streptavidin beads. As control experiments, cohe...
ORGANISM(S): Saccharomyces cerevisiae 
2020-08-31 | GSE157155 | GEO
ProteomicsThe proteome of human amyloid beta oligomers
Amyloid β (Aβ) oligomers are thought to play an important role in the onset and progression of Alzheimer’s disease (AD). Several oligomer-binding proteins have been implicated in mechanisms leading to AD pathology. Such proteins could provide insights into the pathways involved in the disease proces...
ORGANISM(S): Homo sapiens (Human) 
2026-04-07 | PXD053759 | Pride
Alzheimer’s disease Co-immunoprecipitation Mass spectrometry Brain homogenates Amyloid beta oligomer binding 
ProteomicsIP-MS:Protein precipitated by antisense (AS) DNA oligomers crossing the junction site of circNEIL3
To identify the circNEIL3 interacting protein, we performed RNA pull-down assays after transfecting into cells with biotin-labeled sense (S) or antisense (AS) DNA oligomers crossing the junction site of circNEIL3, and the pull-down proteins were subjected to SDS-PAGE and Coomassie blue staining. ~45...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD039394 | Pride
Rna-pulldown Gel-based proteomics Mda-mb-231 cell line 
GenomicsPredicting off-target effects of antisense oligomers targeting bacterial mRNAs with the MASON webserver
Predicting off-target effects of antisense oligomers targeting bacterial mRNAs with the MASON webserver
PRJNA820711 | ENA
ProteomicsThe proteome of APP/PS1 mouse amyloid beta oligomers
Amyloid β (Aβ) oligomers are thought to play an important role in the onset and progression of Alzheimer’s disease (AD). Several oligomer-binding proteins have been implicated in mechanisms leading to AD pathology. Such proteins could provide insights into the pathways involved in the disease proces...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-07 | PXD053785 | Pride
Alzheimer’s disease Co-immunoprecipitation Mass spectrometry Brain homogenates Amyloid beta oligomer binding App/ps1 mouse 
Sort   by:  
 Page size