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MetabolomicsDiel metabolomics analysis of a hot spring chlorophototrophic microbial mat leads to new hypotheses of community member metabolisms
Dynamic environmental factors such as light, nutrients, salt, and temperature continuously affect chlorophototrophic microbial mats, requiring adaptive and acclimative responses to stabilize composition and function. Quantitative metabolomics analysis can provide insights into metabolite dynamics fo...
2024-02-23 | MTBLS187 | MetaboLights
UnknownPointBreak: a randomized phase III study of pemetrexed plus carboplatin and bevacizumab followed by maintenance pemetrexed and bevacizumab versus paclitaxel plus carboplatin and bevacizumab followed by maintenance bevacizumab in patients with stage IIIB or IV nonsquamous non-small-cell lung cancer.
Not available
S-EPMC4881367 | biostudies-literature
ProteomicsAlkyladenine DNA glycosylase associates with transcription elongation to coordinate DNA repair with gene expression
Base excision repair (BER) initiated by alkyladenine DNA glycosylase (AAG; aka MPG) is essential for removal of aberrantly methylated DNA bases. Genome instability and accumulation of aberrant bases accompany multiple diseases including cancer and neurological disorders. While BER is well studied on...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-26 | PXD013508 | Pride
Cancer cachexia  skeletal muscle wasting  muscle atrophy  endurance exercise  aerobic exercise 
ProteomicsEnhanced Proteomic Mapping of Arginine Methylation Using Electron Transfer Dissociation Reveals Novel PRMT5 Substrates and Arginine Trimethylation
PRMT5 is the major enzyme that catalyzes the symmetric dimethylation of arginine (sDMA) in mammalian cells. Its activity is crucial for many biological processes including transcriptional regulation, mRNA processing, as well as DNA damage and repair. However, the protein substrates identified for PR...
ORGANISM(S): Homo sapiens (Human) 
2024-04-30 | PXD037425 | Pride
Prmt5 Etd Methylation Proteomics 
ProteomicsPhosphoproteome Dynamics Mediate Revival of Bacterial Spores
Background: Bacterial spores can remain dormant for decades, yet harbor the exceptional capacity to rapidly resume metabolic activity and recommence life. Although germinants and their corresponding receptors have been known for more than 30 years, the molecular events underlying this remarkable cel...
ORGANISM(S): Bacillus subtilis 
2015-08-27 | PXD002559 | Pride
Bacillus subtilis  spore  phosphoproteome  germination 
ProteomicsAdipose MDM2 regulates systemic insulin sensitivity through nuclear import of MORC2 and the PPARγ cofactor LIPIN1
The intimate association between obesity and type II diabetes urges for a deeper understanding of adipocyte function. We and others have previously delineated a role for the tumor suppressor p53 in adipocyte biology. Here, we show that mice haploinsufficient for MDM2, a key regulator of p53, in thei...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-15 | PXD020812 | Pride
Morc2 Obesity Pparγ C/ebp Mdm2 Lipin1 
UnknownPreexposure chemoprophylaxis for HIV prevention in men who have sex with men.
Not available
S-EPMC3079639 | biostudies-literature
UnknownStatement from the frontal fibrosing alopecia international expert alliance: SOFFIA 2024.
Not available
S-EPMC12843854 | biostudies-literature
UnknownGene expression imputation across multiple brain regions provides insights into schizophrenia risk.
Not available
S-EPMC7034316 | biostudies-literature
UnknownComplement genes contribute sex-biased vulnerability in diverse disorders.
Not available
S-EPMC7319891 | biostudies-literature
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