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ProteomicsHigher-Throughput Proteome Profiling Enabled by Parallelized Pre-Accumulation and Optimized Ion Processing in the Orbitrap Astral Zoom Mass Spectrometer -Tritation Injection time-Astral-zoom
High-throughput proteomics is critical for understanding biological processes, enabling large-scale studies such as biomarker discovery and systems biology. However, current mass spectrometry technologies face limitations in speed, sensitivity, and scalability for analyzing large sample cohorts. The...
ORGANISM(S): Homo sapiens (Human) 
2026-02-16 | PXD066924 | Pride
Dia 300 spd Injection time 
ProteomicsHigher-Throughput Proteome Profiling Enabled by Parallelized Pre-Accumulation and Optimized Ion Processing in the Orbitrap Astral Zoom Mass Spectrometer-300-500 SPD
High-throughput proteomics is critical for understanding biological processes, enabling large-scale studies such as biomarker discovery and systems biology. However, current mass spectrometry technologies face limitations in speed, sensitivity, and scalability for analyzing large sample cohorts. The...
ORGANISM(S): Homo sapiens (Human) 
2026-02-16 | PXD066718 | Pride
300spd 500spd 
Proteomics,MultiomicsmiR-625-3p regulates oxaliplatin resistance by targeting MAP2K6-p38 signaling in human colorectal adenocarcinoma cells
Oxaliplatin (oxPt) resistance in colorectal cancers (CRC) is a major unsolved problem. Consequently, predictive markers and a better understanding of resistance mechanisms are urgently needed. To investigate if the recently identified predictive miR-625-3p is functionally involved in oxPt resistance...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080762 | MassIVE
ProteomicsMetaproteomic profiling of saliva in subjects with periodontitis, dental caries and orally healthy controls
The composition of the salivary microbiota has been reported to differentiate between patients with periodontitis, dental caries and orally healthy individuals. Thus, the purpose of the present investigation was to compare metaproteomic profiles of saliva in oral health and disease. Stimulated saliv...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080763 | MassIVE
ProteomicsProteomics of NGF-TrkA signaling dynamics in neuroblastoma cells
We used quantitative mass spectrometry-based proteomics to unravel global nerve growth factor (NGF)-induced TrkA signaling dynamics at the interactome, phosphoproteome and proteome level. A tetracycline-inducible system for TrkA expression was generated in the human neuroblastoma cell line, SH-SY5Y....
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080834 | MassIVE
ProteomicsPhosphoproteomics analysis of Erk signaling in embryonic stem cell differentiation
Mass spectrometry-based proteomics was applied to unravel Erk signaling in mouse embryonic stem cells (ESCs). A previously described engineered ESCs system for Erk induction via a drug-inducible cRAF-ErT2 fusion (Hamilton, W. B. & Brickman, J. M., Cell Rep 2014) was used in two different setups meas...
ORGANISM(S): Mus musculus (Mouse) 
2019-08-12 | PXD012573 | Pride
Lc-msms Mouse Embryonic stem cells 
ProteomicsOff-line high pH reversed-phase fractionation for in-depth phosphoproteomics
In this study we provide a detailed analysis of the physicochemical characteristics of phosphopeptides, which have been fractionated by off-line high pH chromatography (HpH) before subsequent titanium dioxide (TiO2) enrichment and LC-MS/MS analysis. Our results demonstrate that HpH is superior to st...
ORGANISM(S): Mus musculus (Mouse) 
2014-10-23 | PXD001404 | Pride
Phosphoproteomics  high ph reversed-phase  phosphorylation  peptides  enrichment  fractionation  titanium dioxide  orbitrap 
ProteomicsEvolutionarily-conserved FOXO-regulated OSER1 extends lifespan and healthspan
Molecular aging reflects the time-dependent accumulation of cellular damage and loss of essential cellular functions. FOXO transcription factors and their downstream targets play critical roles in the response to aging-associated cellular damage. Here, we identify and characterize a novel FOXO-regul...
ORGANISM(S): Homo sapiens (Human) 
2024-07-25 | PXD036579 | Pride
Oser1 Lifespan 
ProteomicsComparative proteomics and phosphoproteomics analyses of glucocorticoid responses in breast cancer cell lines
Breast cancer is often treated with glucocorticoids together with chemotherapy to relieve its side effects. However, it has been reported that glucocorticoids promote metastasis of breast cancer. In this study, we conducted quantitative mass-spectrometry to acquire proteome and phosphoproteome to un...
ORGANISM(S): Homo sapiens (Human) 
2026-01-26 | PXD070780 | Pride
Phosphoproteome Glucocorticoid Breast cancer Proteome 
ProteomicsPerformance evaluation of the Q Exactive HF-X for shotgun proteomics
Performance evaluation of the Q Exactive HF-X for shotgun proteomics
ORGANISM(S): Homo sapiens (Human) 
2017-11-30 | PXD006932 | Pride
Q exactive hf-x bottom-up shotgun proteomics q exactive dia dda 
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