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MetabolomicsComprehensive multi-omics analysis reveals the influence of epigenetic mechanisms on porcine oocyte maturation
In vitro maturation (IVM) oocyte is a key component of assisted reproduction in pigs. Asynchronous nucleoplasmic maturation and incomplete cytoplasmic maturation is one of the key factors for impaired maturation and quality of oocytes matured in vitro. Although Single-omics techniques have been appl...
2025-08-27 | MTBLS12325 | MetaboLights
TranscriptomicsComparison of the human oocyte to its sister polar body
Clinicians need additional metrics for predicting quality of human oocytes for IVF procedures. Human polar bodies reflect the oocyte transcript profile. Quantitation of polar body mRNAs could allow for both oocyte ranking and embryo preferences in IVF applications. The transcriptome of a polar body ...
ORGANISM(S): Homo sapiens 
2011-10-12 | E-GEOD-32689 | biostudies-arrayexpress
MetabolomicsGut microbiota-modulated glutamic acid rejuvenates the quality of oocytes deteriorated by advanced reproductive age

The gut microbiota plays a vital role in maintaining the physiological function of host health and the pathogenesis of various diseases. However, its relationship with maternal age-associated decline in oocyte quality remains elusive. Here, we report that establishment of gut microbiota from youn...

2026-05-07 | MTBLS14062 | MetaboLights
GenomicsNEDDylation modifies mitochondrial transcription to maintain oocyte quality (Oocyte)
NEDDylation modifies mitochondrial transcription to maintain oocyte quality (Oocyte)
PRJNA1143033 | ENA
TranscriptomicsObjective molecular criteria for oocyte quality and developmental potential: a proteomic study in inbred mice
Current understanding of oocyte quality and developmental potential maintains that stochastic or epigenetic processes modulate the action of determinants that are laid in the oocyte during oogenesis. These determinants are considered to be rather conserved across mice, leading different strains of m...
ORGANISM(S): Mus musculus 
2016-06-18 | E-MTAB-5013 | biostudies-arrayexpress
TranscriptomicsComparison of transcriptomes between DMSO-5uM and Torin1-5uM treated mouse cumulus-oocyte complexes cultured in vitro for 14h
We sought to identify the potential specific roles of the MTOR signalling in cumulus cells by comparing the transcriptomes of the Control (treated with the DMSO vehicle) and MTOR-specific inhibitor Torin 1(5uM)-treated cumulus-oocyte complexes that were cultured for 16 hours. We compared the transcr...
ORGANISM(S): Mus musculus 
2016-08-01 | E-GEOD-79862 | biostudies-arrayexpress
ProteomicsNEDDylation maintains oocyte quality by stabilizing mitochondrial transcription
As women age, their oocytes decline in both quantity and quality, leading to eventual infertility. Part of this decline is associated with increased levels of reactive oxygen species and decreased mitochondrial function, which are associated with lower live birth rates. However, detailed mechanisms ...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-06 | PXD076100 | Pride
Fertility Nedd8 Oocyte Proteomics Reproduction 
GenomicsNEDDylation modifies mitochondrial transcription to maintain oocyte quality (Ovary)
NEDDylation modifies mitochondrial transcription to maintain oocyte quality (Ovary)
PRJNA1143034 | ENA
ProteomicsUridine restores oocyte quality and mitigates female reproductive aging by inhibition of ferroptosis in mice
Advanced maternal age is a key factor in female infertility, primarily due to declines in ovarian reserve and oocyte quality. However, the metabolic mechanisms underlying reproductive aging remain unclear. Here, we show that uridine levels in the plasma and ovaries of aged mice are significantly red...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-05 | PXD075265 | Pride
Pcbp1 Ferroptosis Uridine Oocyte quality Advanced maternal age 
UnknownImpeding DNA Break Repair Enables Oocyte Quality Control.
Not available
S-EPMC6426715 | biostudies-literature
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