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MetabolomicsClinical efficacy of Yiqi Yangxue formula on knee osteoarthritis and unraveling therapeutic mechanism through plasma metabolites in rats.

OBJECTIVE: To observe the clinical efficacy and safety of Yiqi Yangxue formula (YQYXF) on knee osteoarthritis (KOA), and to explore the underlying therapeutic mechanism of YQYXF through endogenous differential metabolites and their related metabolic pathways.

METHOD...

2024-03-25 | MTBLS5667 | MetaboLights
ProteomicsBenchmarking commonly used software suites and analysis workflows for DIA proteomics and phosphoproteomics
This repository is related to the work "Benchmarking commonly usedsoftware suites and analysis workflows for DIA proteomics and phosphoproteomics". The following files are stored here: 1. four MS datasets generated in this work, including two two-species benchmark datasets acquired on QE HF and tims...
ORGANISM(S): Homo Sapiens Saccharomyces Cerevisiae S288c Mus Musculus 
2022-12-08 | PXD034709 |
UnknownIdentification of Veratrum Species in Pimacao Based on ITS2 Sequences and Steroidal Alkaloids by a Pseudo-Targeted Metabolomics Method.
Not available
S-EPMC9037537 | biostudies-literature
UnknownMetabolomics Analysis of PK-15 Cells with Pseudorabies Virus Infection Based on UHPLC-QE-MS.
Not available
S-EPMC9229976 | biostudies-literature
ProteomicsProteomics of preclinical model of skin dermatitis
To assess the preclinical Aldara model, the proteomic response of mouse skin to topical applied Aldara cream was assessed using untargeted LC-MS. Skin from sham treated or treated with the Aldara cream were compared for 4 independent experiments after 8 days of treatment.
ORGANISM(S): Mus musculus (Mouse) 
2025-04-22 | PXD056245 | Pride
Mouse Orbitrap qe-hf-x Skin 
UnknownExtracellular vesicles from melatonin-preconditioned mesenchymal stromal cells protect human umbilical vein endothelial cells against hypoxia/reoxygenation detected by UHPLC-QE-MS/MS untargeted metabolic profiling.
Not available
S-EPMC12171273 | biostudies-literature
ProteomicsMass spectrometry-based proteomic exploration of diverse murine macrophage cellular models
Immortalised cell lines analogous to their primary cell counterparts are fundamental to research, particularly when large cell numbers are required. Here we report that immortalisation of bone marrow-derived macrophages using the J2-virus resulted in the loss of a protein of interest, MSR1, in wild-...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-28 | PXD051067 | Pride
Msr1 Proteomics Nacrophage 
ProteomicsIdentification of cGAS acetylation and phosphorylation
DNA derived from the genetic material of pathogens or from cellular DNA damage provides a molecular pattern that can be sensed by pattern-recognition receptors of the mammalian innate immune system. In recent years, the cyclic GMP-AMP synthase (cGAS) protein has been characterized as a primary cytos...
ORGANISM(S): Homo sapiens (Human) 
2020-05-11 | PXD017109 | Pride
Human Herpesvirus Affinity purification Ptm Immune response 
ProteomicsWT/SIRT6 KO 293T cell AP-MS anti-CDH1-HA
The study found reciprocal regulation between SIRT6 and APC/C. While SIRT6 is ubiquitinated by APC/C and degraded, CDH1, a co-activator of APC/C, is also deacetylated by SIRT6 and degraded.
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD022402 | Pride
Ap-ms Acetylation 293t 
Proteomics293T cell mitotic AP-MS anti-SIRT6-FLAG 201113
The study found reciprocal regulation between SIRT6 and APC/C. While SIRT6 is ubiquitinated by APC/C and degraded, CDH1, a co-activator of APC/C, is also deacetylated by SIRT6 and degraded.
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD022500 | Pride
Ap-ms Mitosis 293t 
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