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TranscriptomicsDownregulation of LATS kinases alters p53 to promote cell migration
p53 is a pivotal tumor suppressor and a major barrier against cancer. We now report that silencing of the Hippo pathway tumor suppressors LATS1 and LATS2 in non-transformed mammary epithelial cells reduces p53 phosphorylation and increases its association with the p52 NF-?B subunit. Moreover, it par...
ORGANISM(S): Homo sapiens 
2015-12-11 | E-GEOD-74493 | biostudies-arrayexpress
TranscriptomicsCoupling p53 binding and nucleosome occupancy measurements at p53 binding sites
We were interested to explain why p53 binds some high affinity sites in contrast to other high affinity sites that are not bound by p53. p53 binding was measured using p53 ChIP-CHIP and in parallel nucleosome occupancy was measured on these same sites Comparison between p53 binding and nucleosome oc...
ORGANISM(S): Homo sapiens 
2010-08-09 | E-GEOD-22783 | biostudies-arrayexpress
UnknownDown-regulation of LATS kinases alters p53 to promote cell migration.
Not available
S-EPMC4691886 | biostudies-literature
UnknownGenome sequence of the Fleming strain of Micrococcus luteus, a simple free-living actinobacterium.
Not available
S-EPMC2812450 | biostudies-literature
TranscriptomicsRNF20 and USP44 regulate embryonic stem cell differentiation by modulating H2B monoubiquitylation
Embryonic stem cells (ESCs) maintain high genomic plasticity, essential for their capacity to enter diverse differentiation pathways. Post-transcriptional modifications of chromatin histones play a pivotal role in maintaining this plasticity. We now report that one such modification, monoubiquitylat...
ORGANISM(S): Homo sapiens 
2013-01-03 | E-GEOD-33214 | biostudies-arrayexpress
TranscriptomicsNTERA +/-ATRA +/-Cisplatin
investigation of changes in p53-regulated expression levels in ATRA-differentiated and non-differentiated NTERA cells after cisplatin treatment
ORGANISM(S): Homo sapiens 
2011-03-01 | E-MTAB-410 | biostudies-arrayexpress
ProteomicsDownregulation of LATS kinases alters p53 to promote cell migration
p53 is a pivotal tumor suppressor and a major barrier against cancer. We now report that silencing of the Hippo pathway tumor suppressors LATS1 and LATS2 in non-transformed mammary epithelial cells reduces p53 phosphorylation and increases its association with the p52 NF-κB subunit. Moreover, it pa...
ORGANISM(S): Homo sapiens (Human) 
2018-10-25 | PXD003120 | Pride
Cancer Cell-migration Nfkb2 Tp53 Homeostasis Cox-2 
GenomicsCo-transcriptional histone H2B monoubiquitylation is tightly coupled with RNA polymerase II elongation rate
Various histone modifications decorate nucleosomes within transcribed genes. Among these, monoubiquitylation of histone H2B (H2Bub1) and methylation of histone H3 on lysines 36 (H3K36me2/3) and 79 (H3K79me2/3) correlate positively with gene expression. By measuring the progression of the transcripti...
ORGANISM(S): Homo sapiens 
2014-07-15 | E-GEOD-56279 | biostudies-arrayexpress
UnknownReactivation of epigenetically silenced miR-512 and miR-373 sensitizes lung cancer cells to cisplatin and restricts tumor growth.
Not available
S-EPMC4495356 | biostudies-literature
Transcriptomicsp53-repressed miRNAs are Involved with E2F in a Feed Forward Loop Promoting Proliferation
miRNA expression profiles of WI38 primary human fibroblasts with an active or inactive p53. Cells were compared under normal untreated conditions (young and proliferating cells), after DNA damage with Doxorubicin, and upon entry into replicative senescence. Keywords: miRNA, WI-38, p53, GSE56, Senes...
ORGANISM(S): Homo sapiens 
2010-05-19 | E-GEOD-12450 | biostudies-arrayexpress
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