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MetabolomicsRepurposing the orphan drug nitisinone to control the transmission of African trypanosomiasis
Tsetse transmit African trypanosomiasis, which is a disease fatal to both humans and animals. A vaccine to protect against this disease does not exist so transmission control relies on eliminating tsetse populations. Although neurotoxic insecticides are the gold standard for insect control, they neg...
2021-10-06 | MTBLS2166 | MetaboLights
MetabolomicsGlobal untargeted serum metabolomic analyses nominate metabolic pathways responsive to loss of expression of the orphan metallo beta-lactamase, MBLAC1
The C. elegans gene swip-10 encodes an orphan metallo beta-lactamase that genetic studies indicate is vital for limiting neuronal excitability and viability. Sequence analysis indicates that the mammalian gene Mblac1 is the likely ortholog of swip-10, with greatest sequence identity localized...
2019-03-12 | MTBLS650 | MetaboLights
TranscriptomicsThe orphan nuclear hormone receptor ERR-beta controls rod photoreceptor survival.
Mutation of rod photoreceptor-enriched transcription factors is a major cause of inherited blindness. We identified the orphan nuclear hormone receptor ERRβ as selectively expressed in rod photoreceptors. Overexpression of ERRβ induces expression of rod-specific genes in retinas of both wildtype ...
ORGANISM(S): Mus musculus 
2010-07-30 | E-GEOD-21944 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse neural stem cell lines overexpressing Nurr1 to clonal controls
The orphan nuclear receptor Nurr1 has been shown to be critical for the development of ventral midbrain dopaminergic neurons. Consequently, the development of ES cells overexpressing Nurr1 has raised hope for the development of cell replacement therapies for Parkinson's Disease to replace degenerate...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-3571 | biostudies-arrayexpress
Genomicscomplete genome sequencing of Orphan strains
complete genome sequencing of Orphan strains
PRJEB110408 | ENA
ProteomicsOrphan quality control shapes network dynamics and gene expression
All eukaryotes require intricate protein networks to translate developmental signals into accurate cell fate decisions. Mutations that disturb interactions between network components often result in disease, but how composition and dynamics of complex networks are established remains poorly understo...
ORGANISM(S): Homo sapiens (Human) 
2023-05-30 | PXD041519 | Pride
Myc Dsso Ubr5 Proteasome Ubiquitin Orphan quality control Crosslinking 
GenomicsGenome-wide binding of the orphan nuclear receptor TR4 suggests its general role in fundamental biological processes
The orphan nuclear receptor TR4 (human testicular receptor 4 or NR2C2) plays a pivotal role in a variety of biological and metabolic processes. With no known ligand and few known target genes, the mode of TR4 function was unclear. We report the first genome-wide identification and characterization o...
ORGANISM(S): Homo sapiens 
2010-11-15 | E-GEOD-24685 | biostudies-arrayexpress
GenomicsComprehensive analysis of orphan CpG islands identifes novel promoters with conserved DNA methylation dynamics
We report the application of single molecule-based sequencing technology in combination with CXXC affinity purifcation (CAP-seq), MBD affinity purification (MAP-seq) and chromatin immunoprecipitation (ChIP-seq) to generate reciprocal methylation and chromatin modifcation maps in human and mouse. We ...
ORGANISM(S): Mus musculus 
2010-10-04 | E-GEOD-21442 | biostudies-arrayexpress
UnknownInherited retinal dystrophies and orphan designations in the European Union.
Not available
S-EPMC11542323 | biostudies-literature
UnknownInvestigating the landscape of US orphan product approvals.
Not available
S-EPMC6198498 | biostudies-literature
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