Sort   by:  
 Page size 
TranscriptomicsAcutely isolated murine cortical astrocytes and microglia: Alzheimer's disease vs wildtype
Isolation of glia from Alzheimer's mice reveals inflammation and dysfunction. Reactive astrocytes and microglia are associated with amyloid plaques in Alzheimer's disease (AD). Yet, not much is known about the molecular alterations underlying this reactive phenotype. To get an insight into the mole...
ORGANISM(S): Mus musculus 
2015-11-04 | E-GEOD-74615 | biostudies-arrayexpress
ProteomicsProteogenomic subtyping of acute myeloid leukemia and ex-vivo drug response profiling for precision therapies.
We have performed a comprehensive proteomic analysis of clinical patient samples of acute myeloid leukemia (AML) alongside genome-, transcriptome- and ex-vivo drug response profiling.
ORGANISM(S): Homo sapiens (Human) 
2026-03-23 | PXD061758 | Pride
Aml Cancer Proteomics Leukemia Drug screening Therapy 
TranscriptomicsRNA-seq of human tissues
RNA-seq was performed of tissue samples from human individuals representing different tissues in order to study the human tissue transcriptome. This submission contains 14 samples used in the paper A proteogenomics workflow integrating discovery, curation and validation reveals human novel protein c...
ORGANISM(S): Homo sapiens 
2017-08-01 | E-MTAB-5782 | biostudies-arrayexpress
UnknownMolecular evaluation of five different isolation methods for extracellular vesicles reveals different clinical applicability and subcellular origin.
Not available
S-EPMC8298890 | biostudies-literature
TranscriptomicsRNA-seq of A431 cell line after gefitinib treatment
RNA sequencing of A431 cell line samples before and after gefitinib treatment, at 0, 2, 6 and 24 hours, was performed in order to characterize the cell line's early and late response to this drug, and to compare against proteomics (mass spectrometry) characterization of the cell line using the same ...
ORGANISM(S): Homo sapiens 
2016-12-01 | E-MTAB-5285 | biostudies-arrayexpress
ProteomicsImmediate adaption – Quantitative Proteomics of BCL6 silencing and EGFR TK inhibition
We aimed to identify the response mechanism to EGFR tyrosine kinase inhibition. A431 cells were transfected with mock siRNA or BCL6 siRNA. Cells were then treated with gefitinib. Harvesting was done at 0h, at 24h and at 48h. Two TMT10plex sets were organized as follows: TMT set1: mock 0h (3x, channe...
ORGANISM(S): Homo sapiens (Human) 
2020-12-09 | PXD016605 | Pride
Human Bcl6 sirna Tmt proteomics Lc-ms Time course Egfr inhibition Gefitinib A431 cells 
ProteomicsSubCellBarCode: Integrated workflow for robust classification and visualization of spatial proteome
We have developed a mass spectrometry (MS) and bioinformatics-based pipeline to generate a proteome-wide resource of protein subcellular localization across multiple human cancer cell lines (www.subcellbarcode.org). Here, we present a detailed wet-lab protocol spanning from subcellular fractionation...
ORGANISM(S): Homo Sapiens (human) 
2022-09-26 | PXD022533 | JPOST Repository
ProteomicsDEqMS - a method for differential protein expression analysis of quantitative mass spectrometry data
DEqMS is a statistical method to perform differential protein expression (abundance) analysis for quantitative mass spectrometry-based proteomics. Developed on top of Limma, DEqMS implements a robust Bayesian method for accurate variance estimation while taking into account the number of peptide pre...
ORGANISM(S): Homo sapiens (Human) 
2026-06-03 | PXD063099 | Pride
Differential abundance Dia Label-free proteomics Statistical method Differential expression Lc-ms/ms 
ProteomicsHiRIEF deep proteomics of A431 human vulvar cancer cell line and N2A mouse neuroblastoma cell line
Here we present high resolution data from two cancer cell lines. A human cell line, A431 was treated with a drug at different time points and then fractionated into its different subcellular compartments (nuclear, organellar, soluble,whole cell). Protein extracts were trypsinized, peptides separated...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2013-09-27 | PXD000065 | Pride
Mouse Lc-ms Hirief Isoelectric focusing Cancer N2a Human A431 
Proteomics,MultiomicsProteomics of U1810 cells upon treatment with microRNAs with an AAGUGC seed motif.
microRNA dysregulation is a common feature of cancer cells, but the complex roles of microRNAs in cancer are not fully elucidated. Here we used functional genomics to identify oncogenic microRNAs in non-small cell lung cancer and to evaluate their impact on response to EGFR targeting therapy. Our da...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080829 | MassIVE
Sort   by:  
 Page size