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MetabolomicsIntegrated Proteomics and Metabolomics Analysis Reveals Differential Lipid Metabolism in HUVEC under high and low shear stress
OBJECTIVE: Atherosclerotic plaque development is closely associated with the hemodynamic forces applied to endothelial cells (EC). Among these, shear stress (SS) plays a key role in disease development since changes in flow intensity and direction could stimulate an atheroprone or athero...
2019-07-25 | MTBLS739 | MetaboLights
TranscriptomicsExpression profile of human lymphatic endothelial cells under static or oscillatory shear stress conditions in the presence or absence of FOXC2
Lymphatic valves are specialized units regularly distributed along collecting vessels that allow unidirectional forward propulsion of the lymph, and its efficient transport from tissues to the bloodstream. Lymphatic endothelial cells that cover lymphatic valve sinuses are subjected to complex flow p...
ORGANISM(S): Homo sapiens 
2015-11-09 | E-GEOD-60152 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of miR-663 knockdown under shear stress in HUVEC
The mechanisms by which oscillatory shear (OS) induces, while high laminar shear stress (LS) prevents, atherosclerosis are still unclear. Here, we examined the hypothesis that OS induces inflammatory response, a critical atherogenic event, in endothelial cells by a miRNA-dependent mechanism. In part...
ORGANISM(S): Homo sapiens 
2011-03-10 | E-GEOD-20739 | biostudies-arrayexpress
GenomicsOscillatory shear stress induced extracellular vesicles mediate valvular endothelial-interstitial cell crosstalk exacerbating aortic valve calcification
Oscillatory shear stress induced extracellular vesicles mediate valvular endothelial-interstitial cell crosstalk exacerbating aortic valve calcification
PRJNA1281908 | ENA
ProteomicsProteomic profiling of Endothelial Cells Under Laminar Shear Stress Reveals KLF4-mediated Membrane Protein Regulation Compared to Oscillatory Flow
Endothelial cells (EC) are key regulators in vascular homeostasis, and their physiological state depends on hemodynamic forces produced by the blood flow. Laminar shear stress (LSS) maintains endothelial integrity, whereas oscillatory shear stress (OSS) leads to endothelial dysfunction and subsequen...
ORGANISM(S): Homo sapiens (Human) 
2026-09-11 | PXD072355 | Pride
Proteomic signature Membrane subproteome Global proteome Oscillatory shear stress Laminar shear stress Krüppel-like factor 4 Human endothelial cells Tims tof pro2 
Genomics
G3BP2 in Oscillatory Shear Stress-induced Atherosclerosis
PRJNA706049 | ENA
ProteomicsProteomic Evaluation of the Influence of Shear Stress and BRD4-Inhibition on Human Umbilical Vein Endothelial Cells
Atherosclerosis is an important pathological factor in the development of cardiovascular diseases. In addition to increased plasma lipid concentrations, irregular/oscillatory shear stress and inflammatory processes trigger pathophysiological changes. Inhibitors of the transcription modulatory bromo-...
ORGANISM(S): Homo sapiens (Human) 
2022-10-30 | PXD035842 | Pride
Shear stress Brd4 Atherosclerosis Dia-ms Jq1 Endothelial Bet-inhibitor Huvec Proteomics Lc-ms/ms 
GenomicsOscillatory shear stress induced extracellular vesicles mediate valvular endothelial-interstitial cell crosstalk exacerbating aortic valve calcification [RNA-Seq]
Oscillatory shear stress induced extracellular vesicles mediate valvular endothelial-interstitial cell crosstalk exacerbating aortic valve calcification [RNA-Seq]
PRJNA1309687 | ENA
GenomicsOscillatory shear stress induced extracellular vesicles mediate valvular endothelial-interstitial cell crosstalk exacerbating aortic valve calcification [RIP-seq]
Oscillatory shear stress induced extracellular vesicles mediate valvular endothelial-interstitial cell crosstalk exacerbating aortic valve calcification [RIP-seq]
PRJNA1312009 | ENA
TranscriptomicsRNAseq of HUVECs transfected with siRNA targeting Neuropilin 1 (NRP1) (si-NRP1) or a control non-targeting sequence (si-control) and exposed to unidirectional shear stress (20dyns/cm2), oscillatory flow (5dyn/cm2) or kept in absence of flow
HUVECs transfected with siRNA targeting Neuropilin 1(NRP1) (si-NRP1) or a control non-targeting sequence (si-control) and exposed to unidirectional shear stress (20dyns/cm2), oscillatory flow (5dyn/cm2) or kept in absence of flow.
ORGANISM(S): Homo sapiens 
2023-05-23 | E-MTAB-12191 | biostudies-arrayexpress
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