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MetabolomicsGlobal analysis of plasma lipidomics reveals altered lipid signatures in patients with osteonecrosis of the femoral head

AIMS: Although studies have made the connection between lipid metabolism disorder and osteonecrosis of the femoral head (ONFH), the characteristics of the circulating lipidome signature of ONFH have not yet been investigated yet and need to be explored.

METHODS:

2021-07-06 | MTBLS2262 | MetaboLights
TranscriptomicsBisphosphonate related osteonecrosis of the jaw is associated with polymorphisms of the cytochrome P450 CYP2C8 in MM
We have explored the potential role of genetics in the development of osteonecrosis of the jaw (ONJ) in multiple myeloma (MM) patients under bisphosphonate therapy. A genome wide association study was performed using 500.568 single nucleotide polymorphisms (SNPs) in two series of homogeneously treat...
ORGANISM(S): Homo sapiens 
2008-09-25 | E-GEOD-11948 | biostudies-arrayexpress
ProteomicsProteomic analysis of oleuropein effects in steroid-induced osteonecrosis of osteoblasts
This study investigates the therapeutic effects of oleuropein on steroid-induced osteonecrosis of the femoral head. MC3T3-E1 osteoblasts treated with methylprednisolone were used to establish an in vitro model. TMT-based quantitative proteomics was performed to identify differentially expressed prot...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-07 | PXD076592 | Pride
Osteonecrosis Pi3k-akt signaling Proteomics Tmt Osteoblast Apoptosis 
ProteomicsAlendronate and Osteonecrosis of the Jaw
Objectives: Osteonecrosis of the jaw (ONJ), a necrotic bone disease unique to the craniofacial region, is often observed among cancer patients treated with bisphosphonate (BP)-based chemotherapy and becomes a costly and debilitating source of pain and reduced quality of life. Elucidation of clinicop...
ORGANISM(S): Homo sapiens (Human) 
2021-09-10 | PXD024585 | Pride
Ripk3 Osteonecrosis Alendronate Proteomics Wnt/gsk3/b-catenin 
GenomicsSingle cell analysis of Steroid-induced osteonecrosis of the femoral head
Single cell analysis of Steroid-induced osteonecrosis of the femoral head
PRJNA1178322 | ENA
UnknownThe multifaceted roles of extracellular vesicles in osteonecrosis of the femoral head.
Not available
S-EPMC12008682 | biostudies-literature
TranscriptomicsTranscription profiling of human multiple myeloma patients with osteonecrosis of the jaw - a clinical, radiographic, and biomarker characterization
BACKGROUND:; Osteonecrosis of the jaw (ONJ) has been reported in patients with a history of aminobisphosphonate use. METHODS:; In order to define ONJ and gain insights into its pathophysiology, clinical, radiographic, biochemical, and microarray profiling studies were conducted in 11 patients with ...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7116 | biostudies-arrayexpress
GenomicsStem cells from human exfoliated deciduous teeth as a potent cell therapy for refractory osteonecrosis
Stem cells from human exfoliated deciduous teeth as a potent cell therapy for refractory osteonecrosis
PRJNA1459304 | ENA
UnknownThe Role of Immune Regulatory Cells in Nontraumatic Osteonecrosis of the Femoral Head: A Retrospective Clinical Study.
Not available
S-EPMC6886356 | biostudies-literature
ProteomicsAnalysis of components of Buxuetongluo Pills by LC-MS/MS
Buxue tongluo Pills(BTP) are a pill commonly used to treat osteonecrosis of the femoral head, but its composition and mechanism are unclear. As a result, we analyzed the components of BTP by LC-MS/MS.
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD027269 | Pride
Component Lc-ms/ms Buxuetongluo pills 
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