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MetabolomicsUntargeted LC-MS metabolomic comparison of canine osteosarcoma McKinley cells vs normal PEKCC2382 osteoblast cells
Untargeted LC-MS metabolomics analysis was performed on McKinley canine osteosarcoma cells (Group A) and PEKCC2382 normal canine osteoblast cells (Group B). This study screens characteristic differential metabolites and elucidates distinct metabolic phenotype discrepancies between malignant osteosar...
2026-07-28 | MTBLS14700 | MetaboLights
MetabolomicsMethionine Intervention Induces PD-L1 Expression to Enhance the Immune Checkpoint Therapy Response in MTAP-deleted Osteosarcoma
Osteosarcoma (OS), a malignant bone tumor with limited treatment options, exhibits low sensitivity to immune checkpoint therapy (ICT). Through genomics and transcriptomics analyses, we have identified a subgroup of OS with methylthioadenosine phosphorylase (MTAP) deletion, which contributes to ICT r...
2026-06-09 | MTBLS11985 | MetaboLights
TranscriptomicsIntegrative analysis reveals relationships of genetic and epigenetic alterations in osteosarcoma [gene expression]
Osteosarcomas are the most common primary malignant tumours of bone, and almost all conventional osteosarcomas are high-grade tumours showing complex genomic aberrations. We have integrated genome-wide genetic and epigenetic profiles from the EuroBoNeT panel of 19 human osteosarcoma cell lines based...
ORGANISM(S): Homo sapiens 
2012-12-06 | E-GEOD-36001 | biostudies-arrayexpress
TranscriptomicsIntegrative analysis reveals relationships of genetic and epigenetic alterations in osteosarcoma [DNA copy number]
Osteosarcomas are the most common primary malignant tumours of bone, and almost all conventional osteosarcomas are high-grade tumours showing complex genomic aberrations. We have integrated genome-wide genetic and epigenetic profiles from the EuroBoNeT panel of 19 human osteosarcoma cell lines based...
ORGANISM(S): Homo sapiens 
2012-12-06 | E-GEOD-36003 | biostudies-arrayexpress
TranscriptomicsIntegrative analysis reveals relationships of genetic and epigenetic alterations in osteosarcoma [methylation]
Osteosarcomas are the most common primary malignant tumours of bone, and almost all conventional osteosarcomas are high-grade tumours showing complex genomic aberrations. We have integrated genome-wide genetic and epigenetic profiles from the EuroBoNeT panel of 19 human osteosarcoma cell lines based...
ORGANISM(S): Homo sapiens 
2012-12-06 | E-GEOD-36002 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human osteosarcoma Sa OS cells vs reference RNA of human osteosarcoma U-2 OS cells
Osteosarcoma (OS) is a common primary bone malignancy that is characterized by high degree of aneuploidy, gene amplification, and multiple unbalanced chromosomal rearrangements. The human osteosarcoma U-2 OS and Sa OS cells lines have been generated more than three decades ago and are used in a wide...
ORGANISM(S): Homo sapiens 
2009-09-21 | E-MEXP-1897 | biostudies-arrayexpress
TranscriptomicsSyndecan-2 and apoptosis in osteosarcoma
Syndecan-2 was found to act as a tumor suppressor in osteosarcoma and to mediate the apoptotic response to cytotoxic agents. To determine new mechanisms that control cell survival and apoptosis in osteosarcoma cells, we aim to show target genes that are involved downstream of this proteoglycan durin...
ORGANISM(S): Homo sapiens 
2013-09-23 | E-GEOD-19913 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiling by array of human osteosarcoma and their normal bone counterpart
Profiling array: in order to investigate the microRNAs differentially expressed between osteosarcoma and their normal bone counterpart. Specimens were kept at 4 C in RNAlater for up to 1 week, then stored at 80 C. When formal pathologic interpretation of histology from other portions of the biopsy s...
ORGANISM(S): Homo sapiens 
2012-05-21 | E-MTAB-1136 | biostudies-arrayexpress
TranscriptomicsAtorvastatin effect on SaOS2 osteosarcoma cells
SaOS2 osteosarcoma cells were cultured with or without atorvastatin (10 µM) for 6, 15 or 24h (2 biological replcates). RNA were isolated and hybridized to RNG microarrays. Background Osteosarcoma is the most common primary tumor of bone. The rapid development of metastatic lesions and resistance to...
ORGANISM(S): Homo sapiens 
2011-02-22 | E-GEOD-24401 | biostudies-arrayexpress
TranscriptomicsRNA Sequencing Quantitative Analysis of cell lines derived from tumours from two mouse models of human osteosarcoma that recapitulate clinically distinct human osteosarcoma subtypes.
Purpose: Osteosarcoma (OS) is the most common primary bone malignancy. OS consists of several subtypes including fibroblastic, osteoblastic and chondroblastic OS. We have developed genetically engineered mouse models of human OS that recapitulate two distinct subtypes, fibroblastic (Osx-CreLox p53-/...
ORGANISM(S): Mus musculus 
2015-07-06 | E-GEOD-58916 | biostudies-arrayexpress
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