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In this project we applied a workflow for phosphoproteomics analysis to characterize the phosphorylation signalling that is triggered by the cardiotonic steroid ouabain. Ouabain is a ligand for the sodium-potassium ATPase (NKA). Low concentration of ouabain trigger oscillation of intracellular calci...
ORGANISM(S): Chlorocebus sabaeus 
2019-09-13 | PXD010006 | Pride
Spiral ganglion neurons (SGNs) and the associated components of the auditory nerve are primary carriers of auditory information from hair cells to the brain. Loss of SGNs occurs with many pathological conditions, resulting in permanent sensorineural hearing loss. Neural stem/progenitors (NSPs) hav...
ORGANISM(S): Mus musculus 
Transcriptomics analysis of the livers of old mice treated with Ouabain
Ouabain alleviates Mycobacterium abscessus-triggered inflammatory responses through dual regulation of NLRP3 inflammasome activity and M1 macrophage polarization
Mycobacterium abscessus (M. abscessus), one of the most drug-resistant and difficult-to-treat pathogens, primarily causes chronic pulmonary inflammation in humans. The cardiac glycoside ouabain has demonstrated broad-spectrum anti-inflammatory properties in multiple disease models. However, its ther...
ORGANISM(S): Mus musculus 
2025-09-03 | GSE301915 | GEO
Methods: Liver mRNA profiles of 7 weeks old wild-type (WT) and 24 months old mice treated with Vehicle or Ouabain (1mg/Kg)
ORGANISM(S): Mus musculus 
2019-09-03 | GSE122080 | GEO
3' mRNA QuantSeq of microglia/macrophages during zebrafish retinal regeneration following ouabain-induced inner retinal lesion
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