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MetabolomicsGut Microbiome and Metabolome Signatures in Calcium Oxalate Stone Recurrence: A Multi-Omics Study

Background: The incidence and recurrence rate of nephrolithiasis have been increasing annually. Recent evidence highlights a close association between the composition and function of the gut microbiome and the occurrence and recurrence of kidney stones. We performed a multi-omic study to investig...

2026-03-03 | MTBLS13960 | MetaboLights
MetabolomicsMetabolomic Profiling of Oxalate-Degrading Probiotic Lactobacillus acidophilus and Lactobacillus gasseri
Not available
ORGANISM(S): Lactobacillus 
ST001263 | MetabolomicsWorkbench
TranscriptomicsAnalysis of altered LncRNA expression profiles in proximal renal tubular cells in response to calcium oxalate monohydrate crystal adhesion
The present study aims to assess the potential changes in LncRNAs of proximal renal cells in response to the adhesion of calcium oxalate monohydrate (COM) crystals. lncRNA microarray were applied to evaluate the expression of HK-2 cells exposed to COM crystal for 0 and 24 hours.
ORGANISM(S): Homo sapiens 
2014-04-26 | E-GEOD-57111 | biostudies-arrayexpress
TranscriptomicsAnalysis of altered microRNA expression profiles in proximal renal tubular cells in response to calcium oxalate monohydrate crystal adhesion
The present study aims to assess the potential changes in microRNAs of proximal renal tubular cells in response to the adhesion of calcium oxalate monohydrate (COM) crystals. microRNA microarray was applied to evaluate the expression of HK-2 cells exposed to COM crystals for 0 and 24 hours.
ORGANISM(S): Homo sapiens 
2014-04-22 | E-GEOD-56934 | biostudies-arrayexpress
Proteomicsrat kidney LC-MS - Exploring the Therapeutic Mechanism of Desmodium styracifolium on Oxalate Crystal-Induced Kidney Injuries Using Comprehensive Approaches Based on Proteomics and Network Pharmacology
Oxalate-induced kidney injury rat model were established.The differentially expressed proteins in the kidneys between the oxalate and control groups were explored.
ORGANISM(S): Rattus rattus (Black rat) 
2018-10-19 | PXD009496 | Pride
Kidney Lc-ms Rat 
ProteomicsDifferential Protein Expression in HK-2 Cells under Sodium Oxalate and Sodium Selenite Treatments (4D Label Free Proteomics)
This study aims to elucidate differential protein expression in HK-2 cells exposed to sodium oxalate and sodium selenite using 4D label free proteomics.
ORGANISM(S): Homo sapiens (Human) 
2026-03-23 | PXD067701 | Pride
Hk-2 ferroptosis oxalate 
GenomicsExtreme oxalate exposure to gut microbiota
The Effect of High Oxalate Exposure on the Gut Microbiota of Neotoma albigula
PRJEB15421 | ENA
GenomicsExpression factors for oxalate stimulation in HEK293T cells
Expression factors for oxalate stimulation in HEK293T cells
PRJNA775058 | ENA
ProteomicsRaw data for : "Genetic and pharmacological targeting of hepatic oxalate overproduction ameliorates metabolic dysfunction-associated steatohepatitis"
Metabolic dysfunction-associated steatohepatitis (MASH) is on the rise, and with limited pharmacological therapy available, identification of new metabolic targets is urgently needed. Oxalate is a terminal metabolite produced from glyoxylate by lactate dehydrogenase (LDHA). The liver-specific alanin...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2024-04-21 | MSV000094587 | MassIVE
ProteomicsSel1-like Proteins and Peptides are the Major Oxalobatcer formigenes-derived factors Stimulating Oxalate Transport by Human Intestinal Epithelial and Organoid Cells
Kidney stones (KS) are very common, excruciating, and are associated with tremendous healthcare cost, chronic kidney disease (CKD), and end stage renal disease (ESRD). Most KS are composed of calcium oxalate and very small increases in urine oxalate concentration increase the risk for stone formatio...
ORGANISM(S): Oxalobacter formigenes 
2023-07-24 | PXD024992 | Pride
Lc-msms Oxalobatcer formigenes Ltq Kidney stones Chronic kidney disease Lfq quantification 
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