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ProteomicsHDX-MS analysis of p110a in complex with regulatory subunits
HDX-MS was used to map the changes in conformational dynamics in the catalytic subunit of PI3Ka, p110a, in complex with the following five reguatory subunits: p85a, p85b, p55g, p55a, p50a. Apo and pY activated states were also compared between the three splice variants encoded by PIK3R1. No signific...
ORGANISM(S): Homo sapiens (Human) 
2025-11-20 | PXD069057 | Pride
Hdx-ms Pi3ka P85 
GenomicsRole of p110a subunit of PI3-kinase in skeletal muscle mitochondria
Role of p110a subunit of PI3-kinase in skeletal muscle mitochondria
PRJNA511896 | ENA
ProteomicsAdenovirus E4ORF1 activates isoform-specific phosphatidylinositol 3-kinase signaling
The human adenovirus serotype 5 E4ORF1 (Ad5E4ORF1) protein promotes primary endothelial cell survival and angiocrine functions by hijacking the cellular phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway. However, the mechanism by which E4ORF1 activates PI3K in vascular cells remains largely...
ORGANISM(S): Homo sapiens (Human) 
2026-01-05 | PXD069348 | Pride
Adenovirus  akt  angiogenesis  dlg1  e4orf1  endothelium  phosphatidylinositol-3-kinase. 
UnknownRTK-Dependent Inducible Degradation of Mutant PI3Kα Drives GDC-0077 (Inavolisib) Efficacy.
Not available
S-EPMC9762331 | biostudies-literature
UnknownRole of p110a subunit of PI3-kinase in skeletal muscle mitochondrial homeostasis and metabolism.
Not available
S-EPMC6667496 | biostudies-literature
TranscriptomicsAn α-specific PI3K inhibitor improves chemotherapy efficacy by inhibiting hepatic stellate cell activation in liver cancer
The poor response to current systemic treatments in liver cancer has been associated with the activation of cancer-associated fibroblasts (CAFs). Herein, we aimed to investigate the effects of chemotherapy on hepatic stellate cells (HSCs), the main origin of CAFs in liver cancer. In vitro experiment...
ORGANISM(S): Homo sapiens 
2026-01-12 | GSE315789 | GEO
ProteomicsCell rearrangement during angiogenesis requires suppression of actomyosin at cell-cell contacts via PI3-kinase.
Sprouting angiogenesis is a highly dynamic process which relies on the continuous interchange of endothelial cell relative position within the vascular sprout, a process mediated by cell rearrangements. Here we take advantage of a previous identified role of p110a/PI3K regulating endothelial cell mo...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-02 | PXD007060 | Pride
Mascot Pescal Phosphoproteomics Qexactive-plus Mice 
GenomicsEpstein-Barr Virus (EBV) Latent Membrane Protein 1 (LMP1) Regulates Host B Cell miR-155 and its Target FOXO3a via PI3K p110a Activation
Epstein-Barr Virus (EBV) Latent Membrane Protein 1 (LMP1) Regulates Host B Cell miR-155 and its Target FOXO3a via PI3K p110a Activation
PRJNA563335 | ENA
TranscriptomicsEMT Alters Interstitial Fluid Flow-induced Signaling in ERBB2-positive Breast Cancer
A variety of mechanotransduction forces are altered in the tumor microenvironment (TME) and these biophysical forces can influence cancer progression. One such force is interstitial fluid flow (IFF) - the movement of fluid through the tissue matrix. IFF was previously shown to induce invasion of can...
ORGANISM(S): Homo sapiens 
2015-01-06 | E-GEOD-64670 | biostudies-arrayexpress
TranscriptomicsEMT Alters Interstitial Fluid Flow-induced Signaling in ERBB2-positive Breast Cancer
A variety of mechanotransduction forces are altered in the tumor microenvironment (TME) and these biophysical forces can influence cancer progression. One such force is interstitial fluid flow (IFF) - the movement of fluid through the tissue matrix. IFF was previously shown to induce invasion of can...
ORGANISM(S): Homo sapiens 
2015-01-06 | GSE64670 | GEO
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