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Proteomics0N4R Tau and 0N4R Tau P301L Neuronal Interactomes
Human non-mutated 0N4R Tau and P301L mutant 0N4R Tau tagged at the N-terminus with eGFP were expressed in mouse (CD1) primary cortical neurons using adeno associated viruses to monitor early changes in the synaptic interactome beforethe onset of neuronal loss. Affinity purification mass spectrometry...
ORGANISM(S): Mus musculus (Mouse) 
2024-07-03 | PXD044959 | Pride
Mouse neurons Human tau Tau Synapse P301l mutation 
UnknownEarly anterior cingulate involvement is seen in presymptomatic MAPT P301L mutation carriers.
Not available
S-EPMC7876816 | biostudies-literature
UnknownFrontotemporal Dementia P301L Mutation Potentiates but Is Not Sufficient to Cause the Formation of Cytotoxic Fibrils of Tau.
Not available
S-EPMC10573866 | biostudies-literature
UnknownAltered Anterior Insular Metabolic Connectivity in Asymptomatic MAPT P301L Carriers.
Not available
S-EPMC10357174 | biostudies-literature
UnknownDistinct tau filament folds in human MAPT mutants P301L and P301T.
Not available
S-EPMC12350173 | biostudies-literature
UnknownDiverse, evolving conformer populations drive distinct phenotypes in frontotemporal lobar degeneration caused by the same MAPT-P301L mutation.
Not available
S-EPMC7244472 | biostudies-literature
UnknownImpact of the Hereditary P301L Mutation on the Correlated Conformational Dynamics of Human Tau Protein Revealed by the Paramagnetic Relaxation Enhancement NMR Experiments.
Not available
S-EPMC7313075 | biostudies-literature
ProteomicsAre Mouse Models a surrogate for human disease? A temporal, quantitative and molecular perspective.
It is unclear to what extent Tau molecular pathology in murine models reflect human Tauopathies. Nevertheless, mouse models that overexpress human mutant Tau (P301S and P301L) are widely used in studies of Tauopathies and Alzheimer’s Disease (AD). In this study, we perform an in-depth temporally and...
ORGANISM(S): Mus musculus (Mouse) 
2023-02-03 | PXD033965 | Pride
Are mouse models a surrogate for human disease? a temporal Quantitative and molecular perspective. 
UnknownAtrophy patterns in IVS10+16, IVS10+3, N279K, S305N, P301L, and V337M MAPT mutations.
Not available
S-EPMC2754325 | biostudies-literature
UnknownThe role of MAPT gene in Chinese dementia patients: a P301L pedigree study and brief literature review.
Not available
S-EPMC6018486 | biostudies-literature
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