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MetabolomicsPlasmid-encoded toxin defence mediates mutualistic microbial interactions

Gut environments harbour dense microbial ecosystems in which plasmids are widely distributed. Plasmids facilitate the exchange of genetic material among microorganisms while enabling the transfer of a diverse array of accessory functions. However, their precise impact on microbial community compo...

2023-08-10 | MTBLS7248 | MetaboLights
TranscriptomicsCharacterization of Transcription Factor Networks Involved in Umbilical Cord Blood CD34+ Stem Cells-Derived Erythropoiesis
The characteristics of global gene expression patterns during umbilical cord blood (UCB)-CD34+ stem cell-derived erythropoiesis are not clearly elucidated. In this study, UCB-stem cells were grown in liquid culture as a model for this process. We observed a high proliferative capacity of UCB-stem ce...
ORGANISM(S): Homo sapiens 
2013-08-02 | E-GEOD-49438 | biostudies-arrayexpress
TranscriptomicsCharacterization of the transcriptome profiles related to globin gene switching during in vitro erythroid maturation
The fetal and adult globin genes in the human b-globin cluster on chromosome 11 are sequentially expressed to achieve normal hemoglobin switching during human development. The pharmacological induction of fetal g-globin (HBG) to replace abnormal adult sickle bS-globin is a successful strategy to tre...
ORGANISM(S): Homo sapiens 
2012-01-14 | E-GEOD-35102 | biostudies-arrayexpress
TranscriptomicsGene Expression in Transformed Lymphocytes Reveals Phenotype-Modifying Pathways in Cystic Fibrosis
Heritable genetic variants modify cystic fibrosis (CF) clinical phenotypes, e.g., lung disease, age-of-onset of persistent Pseudomonas aeruginosa (P. aeruginosa), and meconium ileus (MI).  Previous genome wide association studies (GWAS) have begun to inform the genetic architecture of CF phenotypes...
ORGANISM(S): Homo sapiens 
2016-05-19 | E-GEOD-60690 | biostudies-arrayexpress
TranscriptomicsFUR- mutant vs. WT
Ferric uptake regulator (Fur) is the major regulator of iron acquisition in Escherichia coli and other bacteria. In the present study, the role of Fur in anaerobic S. enterica serovar Typhimurium was determined by transcriptome analysis, reporter assays, and enzymatic assays. In anaerobic ?fur, 298 ...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium 
2011-10-13 | E-GEOD-18441 | biostudies-arrayexpress
UnknownIntroduction and methods of the evidence-based guidelines for the diagnosis and management of autism spectrum disorder by the Italian National Institute of Health.
Not available
S-EPMC7098105 | biostudies-literature
TranscriptomicsGenetic mosaic analysis of the tumorigenic process distinguishes cell of origin from cell of mutation
Cancer results from molecular mutations occurring in specific cell types, thus determining the cell-of-origin is critical for effective cancer treatment. Inferring such information from terminal tumors can be misleading because malignant tumor cells tend to acquire aberrant properties. Animal models...
ORGANISM(S): Mus musculus 
2011-07-01 | E-GEOD-26676 | biostudies-arrayexpress
TranscriptomicsControl of RNA stability by NrrF, an iron-regulated small RNA in Neisseria gonorrhoeae.
Regulation of gene expression by small non-coding RNAs (sRNAs) plays a critical role in bacterial response to physiological stresses. NrrF, a trans-acting sRNA in Neisseria meningitidis and Neisseria gonorrhoeae, has been shown in the meningococcus to indirectly control, in response to iron (Fe) av...
ORGANISM(S): Neisseria gonorrhoeae 
2013-09-27 | E-GEOD-48526 | biostudies-arrayexpress
TranscriptomicsIron regulation in P. syringae DC3000
DC3000 cultures were grown under highly controlled conditions and after the addition of iron citrate or sodium citrate to the media. In the cultures supplemented with iron, we found that cell-associated iron increased rapidly while culture densities were not significantly different over 4 hours when...
ORGANISM(S): Pseudomonas syringae pv. tomato str. DC3000 
2008-11-07 | E-GEOD-13500 | biostudies-arrayexpress
TranscriptomicsEffects of nitric oxide on Salmonella adapted at pH 4.4
Reactive nitrogen species (RNS) derived from dietary and salivary inorganic nitrates (NO3-) foment innate host defenses associated with the acidity of the stomach. The mechanisms by which these reactive species exert antibiotic activity in the gastric lumen are, however, poorly understood. To iden...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium 
2010-05-26 | E-GEOD-9398 | biostudies-arrayexpress
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