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ProteomicsPrimary angle closure glaucoma is characterized by altered extracellular matrix homeostasis in the iris
Purpose. To characterize the proteome of the iris in primary angle closure glaucoma (PACG). Experimental Design. In this cross-sectional study, iris samples were obtained from surgical iridectomy of 48 adults with PACG and five normal controls. Peptides from iris were analyzed using liquid chromatog...
ORGANISM(S): Homo sapiens (Human) 
2022-03-01 | PXD022292 | Pride
Eye Proteomics Primary angle closure glaucoma Iris Extracellular matrix 
UnknownAssociation of the single nucleotide polymorphisms in the extracellular matrix metalloprotease-9 gene with PACG in southern China.
Not available
S-EPMC2714774 | biostudies-literature
UnknownGenetic Markers PLEKHA7, ABCC5, and KALRN Are Not Associated With the Progression of Primary Angle Closure Glaucoma (PACG) in Malays.
Not available
S-EPMC8592120 | biostudies-literature
UnknownMTHFR C677T predisposes to POAG but not to PACG in a North Indian population: a case control study.
Not available
S-EPMC4108368 | biostudies-literature
UnknownNewly Onset Optic Disc Pit Maculopathy (ODP-M) in a Patient With Primary Angle-closure Glaucoma (PACG) After Surgical Iridectomy: A Case Report.
Not available
S-EPMC7266000 | biostudies-literature
TranscriptomicsAn integrated clinical morphology and functional genomics approach reveals upregulation of PLEKHA7 and C10orf53 in iris contributes to primary angle closure glaucoma [RNA-seq]
Previous Genome-wide association studies (GWASs) have identified susceptibility loci of primary angle closure glaucoma (PACG), but applicating these findings is difficult. Although shallow anterior chamber depth (ACD) and short axial length (AL) are characteristic phenotypes of PACG, current GWAS va...
ORGANISM(S): Homo sapiens 
2024-07-22 | GSE272250 | GEO
OtherAn integrated clinical morphology and functional genomics approach reveals upregulation of PLEKHA7 and C10orf53 in iris contributes to primary angle closure glaucoma [STARR-seq]
Previous Genome-wide association studies (GWASs) have identified susceptibility loci of primary angle closure glaucoma (PACG), but applicating these findings is difficult. Although shallow anterior chamber depth (ACD) and short axial length (AL) are characteristic phenotypes of PACG, current GWAS va...
ORGANISM(S): Homo sapiens 
2024-07-22 | GSE272251 | GEO
GenomicsAn integrated clinical morphology and functional genomics approach reveals upregulation of PLEKHA7 and C10orf53 in iris contributes to primary angle closure glaucoma [ATAC-seq]
Previous Genome-wide association studies (GWASs) have identified susceptibility loci of primary angle closure glaucoma (PACG), but applicating these findings is difficult. Although shallow anterior chamber depth (ACD) and short axial length (AL) are characteristic phenotypes of PACG, current GWAS va...
ORGANISM(S): Homo sapiens 
2024-07-22 | GSE272247 | GEO
ProteomicsAutophagy the key player in trabecular meshwork death-mechanistic difference in early and advanced glaucoma
This study highlights the differential roles of apoptosis versus autophagy in cell death mechanism in the trabecular meshwork in primary adult glaucoma at various stages. This reflects the possible role of autophagy in causing glaucomatous damage in severe disease stages
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD010752 | Pride
Poag Glaucoma Autophagy Trabecular meshwork Proteomics Pacg 
MetabolomicsUntargeted and Targeted Plasma Metabolomics Analysis Identifies Aberrant Amino Acid Metabolism in Early Primary Angle-Closure Glaucoma

Purpose: To explore the plasma metabolite profiles of patients with early primary angle-closure glaucoma (PACG) and investigate their relevance to ocular characteristics and retinal-associated parameters.

Methods：Plasma samples were obtained from 30 early PACG patients and 30 healthy contro...

2026-01-06 | MTBLS13608 | MetaboLights
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