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ProteomicsCharacterization of tumor heterogeneity in beta-catenin mutated hepatocellular adenomas
Hepatocellular adenomas (HCA) are rare benign tumours of the liver which have been extensively classified at the clinico-pathological, genetic and proteomic levels. The b-HCA subtype has several types of mutations in the ß-catenin gene (CTNNB1) with very different clinical phenotypes and risks. Rece...
ORGANISM(S): Homo sapiens (Human) 
2023-05-02 | PXD031323 | Pride
Laser microdissection Tumor heterogeneity Proteomics Hepatocellular adenomas 
ProteomicsDiagnosis of hepatocellular adenomas and malignancy determination by proteomic patterns matching (5)
Biopsies are underrated and underused and our goal was to demonstrate that their inherent expression proteomic pattern could give them an added value for diagnosis. As proof of concept, we used as model hepatocellular adenomas (HCA), well characterized benign liver tumors. From a collection of 260 ...
ORGANISM(S): Homo sapiens (Human) 
2021-06-11 | PXD023000 | Pride
Patterns matching Biopsies Machine learning Clinical proteomics Diagnosis Hepatocellular adenomas Malignancy 
ProteomicsDiagnosis of hepatocellular adenomas and malignancy determination by proteomic patterns matching (4)
Biopsies are underrated and underused and our goal was to demonstrate that their inherent expression proteomic pattern could give them an added value for diagnosis. As proof of concept, we used as model hepatocellular adenomas (HCA), well characterized benign liver tumors. From a collection of 260 c...
ORGANISM(S): Homo sapiens (Human) 
2021-06-11 | PXD022844 | Pride
Patterns matching Biopsies Machine learning Clinical proteomics Diagnosis Hepatocellular adenomas Malignancy 
ProteomicsDiagnosis of hepatocellular adenomas and malignancy determination by proteomic patterns matching (1)
Biopsies are underrated and underused and our goal was to demonstrate that their inherent expression proteomic pattern could give them an added value for diagnosis. As proof of concept, we used as model hepatocellular adenomas (HCA), well characterized benign liver tumors. From a collection of 260 c...
ORGANISM(S): Homo sapiens (Human) 
2021-06-11 | PXD022835 | Pride
Patterns matching Biopsies Machine learning Clinical proteomics Diagnosis Hepatocellular adenomas Malignancy 
ProteomicsDiagnosis of hepatocellular adenomas and malignancy determination by proteomic patterns matching (3)
Biopsies are underrated and underused and our goal was to demonstrate that their inherent expression proteomic pattern could give them an added value for diagnosis. As proof of concept, we used as model hepatocellular adenomas (HCA), well characterized benign liver tumors. From a collection of 260 c...
ORGANISM(S): Homo sapiens (Human) 
2021-06-11 | PXD022839 | Pride
Patterns matching Biopsies Machine learning Clinical proteomics Diagnosis Hepatocellular adenomas Malignancy 
ProteomicsDiagnosis of hepatocellular adenomas and malignancy determination by proteomic patterns matching (2)
Biopsies are underrated and underused and our goal was to demonstrate that their inherent expression proteomic pattern could give them an added value for diagnosis. As proof of concept, we used as model hepatocellular adenomas (HCA), well characterized benign liver tumors. From a collection of 260 c...
ORGANISM(S): Homo sapiens (Human) 
2021-06-11 | PXD022837 | Pride
Patterns matching Biopsies Machine learning Clinical proteomics Diagnosis Hepatocellular adenomas Malignancy 
ProteomicsProteomic analysis of Hepatocellular Adenoma
Hepatocellular adenomas (HCA) are rare benign tumors that constitute a heterogeneous entity, divided into 5 groups based on molecular features (1) H-HCA with inactivating mutations of Hepatocyte Nuclear Factor 1A (HNF1α), (2) inflammatory HCA (IHCA) with diverse mutations activating the JAK/STAT pat...
ORGANISM(S): Homo sapiens (Human) 
2018-03-14 | PXD005571 | Pride
Lc-msms Quantitative proteome Liver Hemorrhage risk Arginine metabolism Hepatocellular adenoma 
ProteomicsProteomic response of diffuse midline glioma to HDAC inhibition reveals adjuvant anti-EBP50 therapy as novel therapeutic concept.
Diffuse midline glioma (DMG) is an aggressive pediatric tumor localized in the brainstem. The median survival after diagnosis is less than one year. Surgical resection is not possible due to the critical localization of the tumor and radiation therapy alone or in combination with chemotherapy show o...
ORGANISM(S): Homo sapiens (Human) 
2021-06-10 | PXD009666 | Pride
Label-free quantitative proteome analysis. Ebp50 Ezrin-radixin-moesin binding protein 50 Diffuse midline glioma Dmg Hdac inhibition 
ProteomicsProteomic analysis of genes regulated by miR-4510 in hepatocellular carcinoma
Patients with advanced hepatocellular carcinoma (HCC) are currently treated by Sorafenib and Regorafenib but efficacy of these multikinase inhibitors is disappointing. Thus, new drugs and therapies are needed to improve HCC management in clinic. We recently reported the remarkable capacity of miR-45...
ORGANISM(S): Homo sapiens (Human) 
2019-10-23 | PXD010085 | Pride
Cancer Liver Hepatocellular carcinoma Mir-4510 Label-free quantitative proteome analysis 
UnknownPrevention of the β-amyloid peptide-induced inflammatory process by inhibition of double-stranded RNA-dependent protein kinase in primary murine mixed co-cultures.
Not available
S-EPMC3131234 | biostudies-literature
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