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ProteomicsIdentification of Ubiquitination site of PAICS by LC-MS/MS
Purines serve as the building blocks for DNA and RNA, confer cellular energy and signaling. Purines are generated by de novo synthesis pathway and salvage pathway. Under purine-depleted or other cellular stresses, enzymes in the purine de novo synthesis pathway form a dynamic and reversible condensa...
ORGANISM(S): Homo sapiens (Human) 
2023-10-06 | PXD038411 | Pride
Ubiquitination site Paics Asb11 
ProteomicsUsing the HA tagged PAICS immunoprecipitation combined with LC-MS for identification of the acetylation sites of PAICS protein in senescent human IMR90 cells at day 10 post oncogene RAS activation
Senescence-associated secretory phenotype (SASP), an established feature of cellular senescence, mediates the biological impacts of senescent cells on tissue microenvironments and contributes to ageing-associated disease progression. We used proximity labeling by turboID combined with LC-MS and iden...
ORGANISM(S): Homo sapiens (Human) 
2025-02-13 | PXD048965 | Pride
Human Imr90 Lc-ms 
ProteomicsUsing proximity labeling by turboID (biotin ligase) fused with PAICS combined with LC-MS for identification of the acetyltransferase associated with PAICS in oncogene RAS activation induced senescent human IMR90 cell
We performed proximity labeling by turboID combined with LC-MS and identified PCAF which interacts with PAICS. Moreover, PCAF promotes the acetylation of PAICS and decreases the protein stability of PAICS. Here, we identify the specific acetyltransferase PCAF that may be involved in the acetylation ...
ORGANISM(S): Homo sapiens (Human) 
2025-02-13 | PXD054616 | Pride
Human Imr90 Lc-ms 
ProteomicsASB11 controls purinosome formation through PAICS ubiquitination
Purine act as building block for DNA and RNA, provide cellular energy and signaling, and can generate cofactors such as NADH and coenzyme A. Purine de novo synthesis pathway begins with amino acids, ribose 5-phosphate, CO2 and NH3 with 6 enzymes and 10 enzymatic steps to convert PRPP to IMP. In prev...
ORGANISM(S): Homo sapiens (Human) 
2023-10-06 | PXD025298 | Pride
Purine de novo synthesis Asb11 Paics Purinosome 
UnknownKnockdown of PAICS inhibits malignant proliferation of human breast cancer cell lines.
Not available
S-EPMC6086025 | biostudies-literature
UnknownPAICS is related to glioma grade and can promote glioma growth and migration.
Not available
S-EPMC8358864 | biostudies-literature
UnknownExpanding clinical spectrum of PAICS deficiency: Comprehensive analysis of two sibling cases.
Not available
S-EPMC12229671 | biostudies-literature
UnknownCrystal structures of human PAICS reveal substrate and product binding of an emerging cancer target.
Not available
S-EPMC7450103 | biostudies-literature
UnknownPAICS mediates DNA damage and cerebellar neuronal loss in C9orf72 amyotrophic lateral sclerosis.
Not available
S-EPMC13634648 | biostudies-literature
UnknownACSS2 drives senescence-associated secretory phenotype by limiting purine biosynthesis through PAICS acetylation.
Not available
S-EPMC11871226 | biostudies-literature
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