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TranscriptomicsC. elegans small RNA sequences from wild type animals fed on sel-1 dsRNA producing bacteria
RNA interference (RNAi) is a phylogenetically widespread gene silencing process triggered by doublestranded RNA (dsRNA). In plants and C. elegans, two distinct populations of small RNAs have been proposed to participate in RNAi : "Primary siRNAs" (derived from Dicer nuclease-mediated cleav...
ORGANISM(S): Caenorhabditis elegans 
2006-11-17 | E-GEOD-6282 | biostudies-arrayexpress
ProteomicsRespiratory effects of exposure to aerosol from the candidate modified-risk tobacco product THS 2.2 in an 18-month systems toxicology study with A/J mice [Lung data]
Smoking cessation is the most effective measure for reducing the risk of smoking-related diseases but switching to less harmful products (modified-risk tobacco products) can be an alternative for smokers who would otherwise not quit. In an 18-month chronic carcinogenicity/toxicity study in A/J mice ...
ORGANISM(S): Mus musculus (Mouse) 
2020-08-13 | PXD016460 | Pride
Lc-msms Mouse Lung Systems toxicology Itraq 
ProteomicsRespiratory effects of exposure to aerosol from the candidate modified-risk tobacco product THS 2.2 in an 18-month systems toxicology study with A/J mice [RNE data]
Smoking cessation is the most effective measure for reducing the risk of smoking-related diseases but switching to less harmful products (modified-risk tobacco products) can be an alternative for smokers who would otherwise not quit. In an 18-month chronic carcinogenicity/toxicity study in A/J mice ...
ORGANISM(S): Mus musculus (Mouse) 
2020-08-13 | PXD016466 | Pride
Lc-msms Respiratory nasal epithelium Mouse Systems toxicology Itraq 
GenomicsAmplification of siRNA in Caenorhabditis elegans generates a transgenerational sequence-targeted histone H3 lysine 9 methylation footprint
Exogenous double-stranded RNA (dsRNA) has been shown to exert homology-dependent effects at the level of both target mRNA stability and chromatin structure. Using C. elegans undergoing RNAi as an animal model, we have investigated the generality, scope, and longevity of chromatin-targeted dsRNA effe...
ORGANISM(S): Caenorhabditis elegans 
2012-01-06 | E-GEOD-32631 | biostudies-arrayexpress
TranscriptomicsDifferential endothelial cell gene expression by African Americans versus Caucasian Americans: A possible contribution to health disparity in vascular disease and cancer
Background: African Americans (AA) have increased burdens of cardiovascular disease and cancer compared to Caucasian Americans (CA). This study addresses the possibility that genetic differences affecting the biology of the vascular endothelium could be a factor contributing to this health disparity...
ORGANISM(S): Homo sapiens 
2010-07-02 | E-GEOD-22688 | biostudies-arrayexpress
ProteomicsPI3Kinase Isoforms in Pancreatic cancer
Pancreatic ductal adenocarcinoma is one of the most lethal cancers, with a 5 year-survival rate below 5%. Lack of curative treatment and failure of targeted therapies urge the need to identify novel efficient therapeutic strategy. Achievement of this goal will be obtained through the identification ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-28 | PXD008410 | Pride
Pi3k signaling pathway isoforms 
ProteomicsRestoring Tumor Immunogenicity with Dendritic Cell Reprogramming
Immune evasion is an important hallmark of cancer ensured by diverse strategies, including immunosuppression and downregulation of antigen presentation. Here, to restore immunogenicity of cancer cells, we employed the minimal gene regulatory network of highly immunogenic type 1 conventional dendriti...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-24 | PXD039789 | Pride
Cancer antigens Cell reprogramming Immunopeptidomics Antigen presentation 
ProteomicsSulfolobus islandicus PTM and quantitative study using bottom-up proteomics
Protein posttranslational methylation and acetylation have been reported to occur in archaea, including the genus Sulfolobus, but have never been characterized on a proteome-wide scale. Among important Sulfolobus proteins carrying such modifications are the chromatin proteins that have been describe...
ORGANISM(S): Sulfolobus islandicus LAL14/1 Escherichia coli 
2016-09-13 | PXD004179 | Pride
Methylation Archaea Sulfolobus islandicus Label-free quantitation Orbitrap fusion Posttranslational modification 
ProteomicsGlobal proteomics reveals distinct muscle adaptations to menstrual cycle phase-based sprint interval training in endurance-trained females
Advances in mass-spectrometry (MS)-based technologies have leveraged our understanding of protein-wide adaptations in human skeletal muscle in response to exercise. However, there is a lack of such data in females, particularly pertaining to already trained females and menstrual cycle phase-based sp...
ORGANISM(S): Homo sapiens (Human) 
2025-08-21 | PXD051852 | Pride
Human Muscle Training Menstrual cycle Lc-ms/ms 
ProteomicsA 6-Month Systems Toxicology Inhalation/Cessation Study in ApoE-/- Mice to Investigate Cardiovascular and Respiratory Exposure Effects of the Modified-Risk Tobacco Products CHTP1.2 and THS2.2 Compared with the Effects of Conventional Cigarettes [Lung iTRAQ data].
Cigarette smoke (CS) causes adverse health effects that may occur shortly after smoking initiation and lead to the development of respiratory disease (chronic obstructive pulmonary disease), cardiovascular disease, and cancer. To reduce the risk of smokers developing smoking-related diseases, Philip...
ORGANISM(S): Mus musculus (Mouse) 
2019-06-18 | PXD010875 | Pride
Mouse Lung Systems toxicology Itraq Lc-ms/ms 
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