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TranscriptomicsTranscription profiling of mouse adult bone marrow cells reveals candidate genes form expansion and transformation of hematopoietic stem cells by NUP98-HOX Fusion Genes
BACKGROUND: Hox genes are implicated in hematopoietic stem cell (HSC) regulation as well as in leukemia development through translocation with the nucleoporin gene NUP98. Interestingly, an engineered NUP98-HOXA10 (NA10) fusion can induce a several hundred-fold expansion of HSCs in vitro and NA10 and...
ORGANISM(S): Mus musculus 
2008-06-17 | E-GEOD-9079 | biostudies-arrayexpress
TranscriptomicsThe role of Hoxa9 and Meis1 in development of acute myeloid leukemia (mRNA)
OBJECTIVE: MEIS1, a HOX cofactor, collaborates with multiple HOX proteins, such as HOXA9, to accelerate the onset of acute myeloid leukemia (AML) through largely unknown molecular mechanisms. To further resolve these mechanisms, we conducted a structure-function analysis of Meis1 and gene expression...
ORGANISM(S): Mus musculus 
2016-09-01 | E-GEOD-75272 | biostudies-arrayexpress
TranscriptomicsLinkage of Meis1 leukemogenic activity to multiple downstream effectors including Trib2 and Ccl3
OBJECTIVE: MEIS1, a HOX cofactor, collaborates with multiple HOX and NUP98-HOX fusion proteins to accelerate the onset of acute myeloid leukemia (AML) through largely unknown molecular mechanisms. MATERIALS AND METHODS: To further resolve these mechanisms, we conducted a structure-function analysis ...
ORGANISM(S): Mus musculus 
2009-04-09 | E-GEOD-15541 | biostudies-arrayexpress
ProteomicsMNX1-mediated Histone Modifications and PBX Family Role in MNX1-AML Leukemogenesis
The t(7;12) AML subtype in pediatric patients is associated with upregulation of homeodomain protein MNX1 as the initiating event for leukemogenesis. In this study, we investigated the downstream targets of MNX1 and their relationship to the histone modifications previously observed to be mediated b...
ORGANISM(S): Mus musculus (Mouse) 
2025-04-24 | PXD056378 | Pride
Pediatric acute myeloid leukemia Pbx T(7 12) Mnx1 
ProteomicsMnx1 Induces Leukemia Transformation Through Altering Histone Methylation in a Model of Pediatric t(7;12) Acute Myeloid Leukemia
Acute myeloid leukemia (AML) in children with cytogenetic aberrations like translocation t(7;12)(q36;p13) is associated with inferior outcome. The translocation can lead to a fusion transcript MNX1::ETV6 but also to activation of MNX1 transcription. We generated an AML mouse model by transplantatio...
ORGANISM(S): Mus musculus (Mouse) 
2024-09-30 | PXD034416 | Pride
Aml Mnx1::etv6 Homeodomain T(7 12) Pediatric aml Mnx1 Methyl-transferases 
TranscriptomicsTranscription profiling of R1 embryonic stem cells cultured for 18h and 72h without leukemia inhibitory factor
R1 ESC were cultured for 18h and 72h without leukemia inhibitory factor
ORGANISM(S): Mus musculus 
2006-10-27 | E-MEXP-414 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human megakaryocytes treated with mild hyperthermia on Mk differentiation
Physical factors can have major influences on the proliferation and differentiation fate of hematopoietic stem cells in culture. Recently, we demonstrated that cord blood CD34+ cells undergo accelerated and increased megakaryocyte differentiation when incubated at 39°C. In this study, we investigat...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-9218 | biostudies-arrayexpress
TranscriptomicsGenome wide methylation array analysis in T-ALL
In short: Genome wide promoter DNA methylation profiling of 43 T-ALL samples and 5 T-cell controls (normal bone marrow and stimulated T-cells) . The Illumina Infinium 27k Human DNA methylation Beadchip v1.2 was used to obtain DNA methylation profiles across approximately 27,000 CpGs. Manuscript abst...
ORGANISM(S): Homo sapiens 
2013-07-01 | E-GEOD-42079 | biostudies-arrayexpress
TranscriptomicsGenome wide gene expression array analysis in T-ALL
In short: The objective with the gene expression array (Illumina HT-12 v.4) analysis of 17 T-ALL samples was to correlate gene expression levels with DNA promoter methylation status. Manuscript Abstract: Background: Treatment of pediatric T-cell acute lymphoblastic leukemia (T-ALL) has improved, but...
ORGANISM(S): Homo sapiens 
2013-07-01 | E-GEOD-41621 | biostudies-arrayexpress
TranscriptomicsCell of origin in AML: Susceptibility to MN1-induced transformation is regulated by the MEIS1/abdB-like HOX protein complex
The molecular mechanism defining susceptibility of normal cells to oncogenic transformation may be a valuable therapeutic target. We characterized the cell of origin and its critical pathways in MN1 leukemias. Common myeloid (CMP), but not granulocyte-macrophage progenitors (CMP) could be transforme...
ORGANISM(S): Mus musculus 
2011-05-19 | E-GEOD-22923 | biostudies-arrayexpress
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