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ProteomicsHDL proteome across 93 mouse strains
High-density lipoproteins (HDL) are nanoparticles with >80 associated proteins, phospholipids, cholesterol and cholesteryl esters. We have identified and quantified the ultracentrifugation isolated HDL proteome across 93 strains of mice, a diverse inbred strains of mice, Hybrid Mouse Diversity Panel...
ORGANISM(S): Mus musculus (Mouse) 
2019-04-24 | PXD009473 | Pride
Hdl Strains Mouse 
ProteomicsExtended multiplexing of TMT labeling reveals age and high fat diet specific proteome changes in mouse epididymal adipose tissue
Age-related and/or high caloric intake driven changes in visceral adipose tissue contribute to the development of diabetes and cardiovascular disease. The lack of reliable, high-throughput methods to analyze the adipose tissue protein composition has limited our understanding of the protein network...
ORGANISM(S): Mus musculus (Mouse) 
2017-03-27 | PXD005953 | Pride
Protein expression Low fat diet Mudpit Proteomics Internal reference scaling normalization High fat diet Mouse Extended multiplexing Epididymal adipose tissue Aging Tandem mass tags Orbitrap fusion 
ProteomicsExtended multiplexing of TMT labeling reveals age and high fat diet specific proteome changes in mouse epididymal adipose tissue
Age-related and/or high caloric intake driven changes in visceral adipose tissue contribute to the development of diabetes and cardiovascular disease. The lack of reliable, high-throughput methods to analyze the adipose tissue protein composition has limited our understanding of the protein network...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2018-07-03 | MSV000082569 | MassIVE
ProteomicsThe Effect of Fish Oil Supplementations on HDL Proteome, Lipidome and Function
Seven health subjects took fish oil supplements (1.125 mg DHA and 875 mg EPA) for 30 days.Prior to supplementation, at 30 day of supplementation and after a 30 day washout period patient plasma was collected. From subject plasma HDL was isolated using a two step ultracentrifugation procced. The isol...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD041728 | Pride
Dha Fish oils Epa Hdl 
ProteomicsProteome-wide diet-independent adipose tissue alterations link dendritic cells to 2-aminoadipoate associated insulin sensitivity.
Adipose tissue dysfunction in obese humans is associated with disrupted metabolic homeostasis, insulin resistance, and type 2 diabetes mellitus (T2DM). In a mouse model that has preserved insulin sensitivity despite increased adiposity, we used unbiased three-dimensional integration of proteome prof...
ORGANISM(S): Mus musculus (Mouse) 
2018-08-06 | PXD008660 | Pride
Insulin resistance Isobaric labeling Adipose tissue biology Inflammation Extended multiplexing Branched chain amino acid metabolism Quantitative proteomics Obesity 
ProteomicsHDL proteome remodeling post-stroke
Prospective cohort studies and meta-analyses examining the relationship between HDL-cholesterol (C) and stroke risk are discordant and question the value of HDL-C as a marker for stroke risk prediction. However, the relationship between other metrics of HDL, function and proteome, and stroke remain ...
ORGANISM(S): Homo Sapiens 
2021-01-24 | PXD015001 | panorama
ProteomicsTumour mtDNA mutations drive aerobic glycolysis to enhance checkpoint blockade (part 2)
Mitochondrial DNA (mtDNA) encodes essential machinery for respiration and metabolic homeostasis but is paradoxically among the most common targets of somatic mutations in the cancer genome, with truncating mutations in complex I genes being over-represented1 . While mtDNA mutations have been associ...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-08 | PXD044987 | Pride
Melanoma Cancer Complex i Mitochondrial dna 
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