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TranscriptomicsTranscription profiling of mouse resting and activated CD8+ T cells
This experiment compared the expression of mRNAs and noncoding RNAs between resting and activated CD8+ effector T cells, with the primary aim of identifying noncoding RNAs that were dynamically regulated during T cell activation.
ORGANISM(S): Mus musculus 
2008-11-01 | E-TABM-491 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse naive and memory CD8+ T cells
This experiment compared the expression of mRNAs and noncoding RNAs between naive and memory CD8+ T cells, with the primary aim of identifying noncoding RNAs that were dynamically regulated during T cell differentiation.
ORGANISM(S): Mus musculus 
2008-11-01 | E-TABM-492 | biostudies-arrayexpress
ProteomicsIdentification of NPGPx-interacting proteins in activated T cells
The tyrosine kinase, ζ-chain-associated protein of 70 kDa (ZAP70), is essential for T cell development and activation. However, it remains elusive whether a direct redox regulation affects ZAP70 activity upon TCR stimulation. Here, we showed that deficiency of non-selenocysteine containing phospholi...
ORGANISM(S): Homo sapiens (Human) 
2021-01-25 | PXD017046 | Pride
T cell activation Zap70 Npgpx 
TranscriptomicsInterference of B-Cell and T-Cell Receptor Genes in Single-Cell RNA Sequencing Data
B and T cells play central roles in immune responses and, as such, are integral in many diseases, such as autoimmunity. Characterizing these cells, their subsets, and exploring their transcriptomes to understand the underlying biology, can be achieved using single-cell RNA sequencing (scRNA-seq). Wh...
ORGANISM(S): Homo sapiens 
2025-12-16 | E-MTAB-12346 | biostudies-arrayexpress
TranscriptomicscDNA microarray analysis of splenic B220+CD138+ plasma cells from K/BxNsf and K/BxN mice
Long-lived plasma cells (LLPCs) develop under the help of follicular helper T (Tfh) cells and reside mainly in the bone marrow. However, these cells are unusually abundant in the spleen of several autoimmune models including K/BxNsf mice, yet their pathogenic impact remains unknown. To investigate a...
ORGANISM(S): Mus musculus 
2016-03-01 | E-GEOD-66947 | biostudies-arrayexpress
MetabolomicsLung Lipidomic Alterations in Beagle Dogs Infected with Toxocara canis

Toxocariasis, mainly caused by Toxocara canis, and to a lesser extent, Toxocara cati, is a neglected parasitic zoonosis. The mechanisms that underlie the changes in lipid metabolism of T. canis infection in Beagle dogs' lungs remain unclear. Lipidomics is a rapidly emer...

2023-08-21 | MTBLS5583 | MetaboLights
UnknownIL-15 overexpression promotes memory program and anti-tumor activity of CD64 CAR T cells in a preclinical AML model.
Not available
S-EPMC12909298 | biostudies-literature
MetabolomicsBranched-chain ketoacids derived from cancer cells modulate macrophage polarization and metabolic reprogramming

Macrophages are prominent immune cells in the tumor microenvironment that can be educated into pro-tumoral phenotype by tumor cells to favor tumor growth and metastasis. The mechanisms that mediate a mutualistic relationship between tumor cells and macrophages remain poorly characterized. Here, w...

2022-10-03 | MTBLS4497 | MetaboLights
Unknownγδ T-cell autoresponses to ectopic membrane proteins: a new type of pattern recognition.
Not available
S-EPMC11955531 | biostudies-literature
UnknownIL-21 Optimizes the CAR-T Cell Preparation Through Improving Lentivirus Mediated Transfection Efficiency of T Cells and Enhancing CAR-T Cell Cytotoxic Activities.
Not available
S-EPMC8220804 | biostudies-literature
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