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ProteomicsDEAD box RNA helicases are pervasive protein kinase interactors and activators
DEAD box (DDX) RNA helicases are a large family of ATPases, many of which have unknown functions. There is emerging evidence that besides their role in RNA biology, DDX proteins may stimulate protein kinases. To investigate if protein kinase-DDX interaction is a more widespread phenomenon, we conduc...
ORGANISM(S): Homo sapiens (Human) 
2024-03-10 | PXD043289 | Pride
Kinase activators Rna helicases Interactome 
ProteomicsDNMT and HDAC inhibition induces immunogenic neoantigens from human endogenous retroviral element-derived transcripts
Immunotherapies targeting cancer-specific immunogenic neoantigens have revolutionized the treatment of cancer patients. Recent evidence suggests that epigenetic therapies could synergize with immunotherapies, mediating the de-repression of endogenous retroviral element (ERV)-encoded promoters, and t...
ORGANISM(S): Homo sapiens (Human) 
2023-09-13 | PXD035748 | Pride
Decitabine Dnmt Hla Ltr Cancer Erv Mhc Neoantigen Hdac Sb939 Immunopeptidomics Immunotherapy 
ProteomicsMYT1L haploinsufficiency in human neurons and mice causes autism-associated phenotypes that can be reversed by genetic and pharmacologic intervention
MYT1L is an autism spectrum disorder (ASD)-associated transcription factor that is expressed in virtually all neurons throughout life. How MYT1L mutations cause neurological phenotypes and whether they can be targeted remains enigmatic. Here, we examine the effects of MYT1L deficiency in human neuro...
ORGANISM(S): Mus musculus (Mouse) 
2023-02-20 | PXD037867 | Pride
Myt1l Autism Human neurons 
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