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MetabolomicsMitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis
Somatic DNMT3A R882 codon mutations drive the most common form of clonal haematopoiesis (CH) and are associated with increased acute myeloid leukaemia (AML) risk1,2. Preventing expansion of DNMT3A-R882-mutant haematopoietic stem/progenitor cells (HSPCs) may therefore avert progression to AML. To ide...
2025-02-06 | MTBLS12201 | MetaboLights
ProteomicsDNA methyltransferase (DNMT) associated proteins in human malaria parasite Plasmodium falciparum
This study identified Plasmodium falciparum DNA methyltransferase (DNMT)associated proteins in parasite cytosol and nucleus, including RNA binding proteins and AP2-domain containing proteins, indicating this protein is involved in RNA process and transctiptional regulation.
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2023-07-20 | PXD032860 | Pride
Plasmodium falciparum Dna methyltransferase (dnmt) 
GenomicsTargeted bisulfite sequencing to detect TALE-DNMT mediated targeted DNA methylation in human cells
We use NGS to assess the ability of TALE-guided DNA methyltranferases to make targeted changes to DNA methylation Targeted bisulfite sequencing of cells infected with wild-type or mutant TALE-DNMT constructs directed to the CDKN2A (p16) locus
ORGANISM(S): Homo sapiens 
2015-05-01 | E-GEOD-66456 | biostudies-arrayexpress
ProteomicsDNMT and HDAC inhibition induces immunogenic neoantigens from human endogenous retroviral element-derived transcripts
Immunotherapies targeting cancer-specific immunogenic neoantigens have revolutionized the treatment of cancer patients. Recent evidence suggests that epigenetic therapies could synergize with immunotherapies, mediating the de-repression of endogenous retroviral element (ERV)-encoded promoters, and t...
ORGANISM(S): Homo sapiens (Human) 
2023-09-13 | PXD035748 | Pride
Decitabine Dnmt Hla Ltr Cancer Erv Mhc Neoantigen Hdac Sb939 Immunopeptidomics Immunotherapy 
ProteomicsThe type of DNA damage response after Decitabine treatment depends on the level of DNMT activity
Decitabine and Azacytidine are considered as epigenetic drugs that induce DNA-methyltransferase (DNMT)-DNA crosslinks, resulting in DNA-hypomethylation and -damage. Although they are already applied against myeloid cancers, important aspects of their mode of action remain unknown, highly limiting th...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-19 | PXD045353 | Pride
Spatial proteomics 5-aza-2'-deoxycytidine Protein-dna crosslinks Azacytidine 
ProteomicsDNMT and HDAC inhibition induces immunogenic neoantigens from human endogenous retroviral element-derived transcripts
Immunotherapies targeting cancer-specific neoantigens have revolutionized the treatment of cancer patients. Recent evidence suggests that epigenetic therapies synergize with immunotherapies, mediated bythe de-repression of endogenous retroviral element (ERV)-encoded promoters, and the initiation of ...
ORGANISM(S): Homo sapiens (Human) 
2023-08-18 | PXD035750 | Pride
Decitabine Ltr Cancer Erv Mhc Neoantigen Dnmt Hla Hdac Sb939 Immunopeptidomics Humna Immunotherapy 
GenomicsTranscriptome induced by DNMT degrader in ccRCC cells
Transcriptome induced by DNMT degrader in ccRCC cells
PRJNA1036650 | ENA
UnknownTwo-stage case-control study of DNMT-1 and DNMT-3B gene variants and breast cancer risk.
Not available
S-EPMC3493111 | biostudies-literature
TranscriptomicsDNMT inhibition in the Neonatal Preoptic Area
PN2 male and female rat pups were treated with vehicle or zebularine. POA RNA was extracted and sequenced to deterime the effects of DNMT inhibition in POA gene expression. Males and Females were treated with either vehicle (0.1% DNMSO in saline) or Zebularine
ORGANISM(S): Rattus norvegicus 
2015-03-30 | E-GEOD-66203 | biostudies-arrayexpress
TranscriptomicsLong term DNMT inhibition in SKM1 cells
SKM-1 cells were cultured for 28 days in the absence or presence of low doses of the DNMT1 inhibitors DAC (10 nM) or AZA (100 nM). The experiment was carried in two independent set at different times, and with 2 replicates for each condition (Ctl, AZA, DAC) for a total of 12 samples. The SKM-1 cell ...
ORGANISM(S): Homo sapiens 
2013-12-11 | E-MTAB-2130 | biostudies-arrayexpress
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