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ProteomicsMrc1 facilitates epigenetic inheritance through proper parental histone segregation
Chromatin-based epigenetic memory relies on the equal distribution of parental histone tetramers, which serve as templates for duplicating parental chromatin, to newly synthesized daughter DNA strands. Histone chaperones within the replisome, such as the histone binding domains (HBDs) of Mcm2 and Po...
ORGANISM(S): Schizosaccharomyces Pombe (ncbitaxon:4896) 
2023-07-16 | MSV000092452 | MassIVE
ProteomicsHistone dynamics at replication forks in embryonic stem cells
We employ inducible mutants to dissect the early and late consequences of impaired histone recycling. We find rapid accumulation of H3K27me3 in response to impaired histone recycling, preceding gene expression changes. Simultaneous disruption of both leading (POLE4) and lagging strand (MCM2-2A) recy...
ORGANISM(S): Mus musculus (Mouse) 
2025-01-12 | PXD053300 | Pride
Parental histones Pole4 Mcm2 Escs 
GenomicsRecycling of parental histones preserves the epigenetic landscape during embryonic development (CUTAC)
Recycling of parental histones preserves the epigenetic landscape during embryonic development (CUTAC)
PRJNA840914 | ENA
GenomicsRecycling of parental histones preserves the epigenetic landscape during embryonic development (RNA-seq)
Recycling of parental histones preserves the epigenetic landscape during embryonic development (RNA-seq)
PRJNA840917 | ENA
GenomicsRecycling of parental histones preserves the epigenetic landscape during embryonic development (ATAC-seq)
Recycling of parental histones preserves the epigenetic landscape during embryonic development (ATAC-seq)
PRJNA840915 | ENA
GenomicsRecycling of parental histones preserves the epigenetic landscape during embryonic development (CUT&Tag)
Recycling of parental histones preserves the epigenetic landscape during embryonic development (CUT&Tag)
PRJNA840913 | ENA
GenomicsRecycling of parental histones preserves the epigenetic landscape during embryonic development (STRIPE-seq)
Recycling of parental histones preserves the epigenetic landscape during embryonic development (STRIPE-seq)
PRJNA840928 | ENA
ProteomicsN-terminus of Spt16 anchors FACT to Mcm2 for parental histone recycling
Parental histone recycling is essential for the restoration of chromatin-based epigenetic information during chromatin replication; however, the specific mechanisms underlying the local recycling of parental histones remain poorly understood. Here, we reveal an unexpected role of the Spt16-N domain ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-01-26 | PXD043392 | Pride
Mcm2-7 Fact，parental histone recycling 
GenomicsPartitioning of Parental Histones Between Leading and Lagging Strands is Modulated by DNA Polymerase Dosage
Partitioning of Parental Histones Between Leading and Lagging Strands is Modulated by DNA Polymerase Dosage
PRJNA1450547 | ENA
GenomicsSymmetric inheritance of parental histones governs epigenome maintenance and stem cell identity
Symmetric inheritance of parental histones governs epigenome maintenance and stem cell identity
PRJNA646113 | ENA
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